The main objective is to quantify and compare sucrose hydrolysis by sucrase and glucose absorption and glycaemic response of added arabinose to liquid and solid sucrose containing food products.
ID
Bron
Verkorte titel
Aandoening
Eating behaviour, obesity, overweight, diabetes
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Plasma glucose and insulin levels
Doel van het onderzoek
The main objective is to quantify and compare sucrose hydrolysis by sucrase and glucose absorption and glycaemic response of added arabinose to liquid and solid sucrose containing food products.
Onderzoeksopzet
Every subject will visit the laboratory 7 times:
1. For an information meeting;
2. For a screening meeting;
3. 5 testsessions with in each session:
A. Plasma glucose and insulin levels and breath sample collection: 2 times before start of the treatment, and at 15, 30, 45, 60, 90, 120, 150, and 180 minutes after start of the treatment.
B. VAS questionnaire: Directly before, and at 15, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240, and 270 minutes after start of the treatment;
C. Ad libitum test meal at 240 minutes after start of the treatment;
D. Gastro-intestinal comfort directly before and at 180 and 270 minutes after start of the treatment.
Onderzoeksproduct en/of interventie
1) Control drink; 2) Xylose drink; 3) Arabinose drink; 4) Control muffin; and 5) Arabinose muffin
Algemeen / deelnemers
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Wetenschappers
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Male
- 18-35 Years old while signing the informed consent
- Good Dutch speaking, writing, understanding
- Healthy: as judged by the subject
- BMI: 18.5-25 kg/m2
- Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session
- Normal fasting glucose concentration <6.1 mmol/L
- Normal hemoglobine (Hb) concentration >8.5 mmol/L
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Allergy, intolerance or oversensitivity for the food products under study
- Having a history of medical or surgical events that may affect the study outcome
- Having reported gastro-intestinal problems
- Medical drug use that may affect the study outcome
- Current antibiotics usage or in the two months prior to the screening session
- Not willing to eat muffins or to drink fruit-based drinks
- Being a vegetarian (not willing to eat meat)
- Use of dietary supplements that may affect the study outcome
- Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session
- Excessive alcohol consumption (>21 glasses/week on average)
- Elite athletes, i.e. exercise > 7h/week vigorously
- Planning to change physical activity pattern during the study period
- Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse
- Recent blood donation (<1 month prior to day 1 of the study)
- Not willing to donate blood during the study
- Not having a general practitioner
- Being an employee of Wageningen University, department of Human Nutrition
- Current participation in other research
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4818 |
| NTR-old | NTR5319 |
| CCMO | NL51738.081.15 |
| OMON | NL-OMON42017 |