The objective of the study is to gain more insight into brain damage in infants with congenital heart disease. We hypothesize that infants with congenital heart disease are at risk of developing brain damage during early life or even before birth.
ID
Bron
Verkorte titel
Aandoening
Congenital heart disease, ductus arteriosus, near-infrared spectroscopy, Doppler flow profiles, general movements, Prechtl's method, neurological outcome, neonate
Congenitale hartafwijkingen, ductus arteriosus, near-infrared spectroscopy, Doppler flow profielen, general movements, Prechtl's methode, neurologische ontwikkeling, neonaat
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
General movements (GMs) according to Prechtl's method
Achtergrond van het onderzoek
Infants with congenital heart disease are at risk of developing brain damage. This study is designed to gain more insight into the timing of brain damage via non-invasive clinical tools such as antenatal Doppler flow profiles, multisite near-infrared spectroscopy and general movements according to Prechtl's method.
Doel van het onderzoek
The objective of the study is to gain more insight into brain damage in infants with congenital heart disease. We hypothesize that infants with congenital heart disease are at risk of developing brain damage during early life or even before birth.
Onderzoeksopzet
From diagnosis before birth to an age of three months.
GMs: age of seven days and age of three months
NIRS: day 1-7 after birth, during and after corrective surgery
Antenatal Doppler flow profiles: every 4 weeks after diagnosis
Onderzoeksproduct en/of interventie
none
Algemeen / deelnemers
kinderarts-neonatoloog, afdeling neonatologie
Beatrix Kinderziekenhuis, UMC Groningen
Huispostcode: CA 51
Hanzeplein 1
Postbus 30001
Groningen 9700 RB
The Netherlands
050-3614215
e.kooi@umcg.nl
Wetenschappers
kinderarts-neonatoloog, afdeling neonatologie
Beatrix Kinderziekenhuis, UMC Groningen
Huispostcode: CA 51
Hanzeplein 1
Postbus 30001
Groningen 9700 RB
The Netherlands
050-3614215
e.kooi@umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
A cardiac anomaly on ultrasound before birth
Admission to the NICU after birth
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Premature birth before a gestational age of 36 weeks
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5101 |
| NTR-old | NTR5233 |
| CCMO | NL45567.042.14 |
| OMON | NL-OMON40142 |