We expect that Parkinson's disease patients will show an impairment in feedback and feedforward speech control mechanisms when compared to healthy age- and gender-matched control speakers.
ID
Bron
Verkorte titel
Aandoening
Parkinson's disease
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease to adult control speakers.
Achtergrond van het onderzoek
Despite doing it almost without effort, speaking is a highly complex task requiring precisely timed and linguistically-driven coordination of the lungs, vocal folds and speech articulators (e.g. lips, tongue). This process, speech motor control, relies on both feedforward (pre-planned movements based on stored movement representations drawn from past experiences) and feedback (monitoring sensory input relative to what is expected) control mechanisms. Research suggests that these mechanisms may be impaired in Parkinson’s disease (PD) patients. However, current findings have resulted from studies with small samples and heterogeneous PD groups.
The central aim of this project is to identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease and healthy adults. Specifically, we will investigate how participants cope with feedback perturbations in speech, by measuring both the resulting acoustic speech signal and the underlying speech motor articulation using electromagnetic articulography and ultrasound tongue imaging. To assess whether the potential impairments of the feedback and feedforward system are speech-specific or more general (as PD is a movement disorder), we will also conduct feedback perturbation experiments in non-speech motor movement tasks.
The innovative combination of these methods will enable us to identify whether and how impairments of speech planning and monitoring are related to the progression of PD. Furthermore, the extent to which PD patients cope with feedback perturbations compared to healthy adults may potentially serve as a diagnostic marker for the disease.
Doel van het onderzoek
We expect that Parkinson's disease patients will show an impairment in feedback and feedforward speech control mechanisms when compared to healthy age- and gender-matched control speakers.
Onderzoeksopzet
Session 1, session 2 (taking place within a month of session 1)
Onderzoeksproduct en/of interventie
N. A.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- 40 years or older
- Native speaker of Dutch
Only for the PD group:
- Diagnosed with idiopathic Parkinson’s disease (according to the UK Parkinson’s Disease Society Brian Bank Clinical Diagnostic Criteria)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- A score of 2 or higher on part 1.1 (cognitive impairment) or part 1.2 (hallucinations and psychosis) of the MDS-UPDRS
- History of neurological or psychological disorders
- Self-reported signs of depression
- Self-reported severe swallowing problems
- Stuttering or other pre-existing speech and language problems (not occurring as a symptom of parkinsonian hypokinetic dysarthria)
- Non-removable metal on-, in- or close to the head (e.g., piercings, dental braces, medical devices such as deep brain stimulation electrodes)
- Having a pacemaker
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9381 |
| CCMO | NL72589.042.21 |
| OMON | NL-OMON55196 |