To investigate the feasibility of aspiration of synovia/ fluid from inflamed small OA hand joints and in case synovia/ fluid can be obtained, to investigate which analyses can be performed on the amount of fluid obtained.
ID
Bron
Verkorte titel
Aandoening
Hand osteoarthritis (OA), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The percentage of study joints in which a successful aspiration is performed.
Achtergrond van het onderzoek
Hand osteoarthritis (OA) is a prevalent disease of which the aetiology is largely unknown. Synovitis can frequently be found in hand joints of OA patients with the use of imaging modalities such as ultrasonography (US). Although synovitis is thought to be involved in clinical features and development of structural damage, its exact role is currently not elucidated. Therefore, the investigation of synovia/ tissue would be of great interest.
However, synovia/ tissue can only be obtained via an invasive procedure, which is not easy
in small hand joints. Alternatively, it might be possible to obtain synovia/ fluid, which is a
reflection of the processes going on in the synovia/ tissue, and is therefore also of interest to study.
Doel van het onderzoek
To investigate the feasibility of aspiration of synovia/ fluid from inflamed small OA hand joints
and in case synovia/ fluid can be obtained, to investigate which analyses can be performed
on the amount of fluid obtained.
Onderzoeksopzet
single study visit
Onderzoeksproduct en/of interventie
not applicable
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Diagnoses of hand OA, rheumatoid arthritis, or psoriatic arthritis according to recognised classification criteria sets;
2. Presence of an inflamed interphalangeal or MCP joint for which the treating rheumatologist has proposed treatment with an intra-articular injection with corticosteroids;
3. Patients should be 40 years of age or older.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients that had an intra-articular injection with corticosteroids, an operation or an important trauma in the same joint less than 12 weeks before the intended injection;
2. The presence of a chronic inflammatory disease (other than OA, rheumatoid
arthritis or psoriatic arthritis), such as poly-articular gout;
3. Contra-indication for an intra-articular injection such as anti-coagulant (vitamin K
antagonist) use that can't be discontinued.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7283 |
| NTR-old | NTR7517 |
| CCMO | NL61359.058.17 |
| OMON | NL-OMON53105 |