In the current proposal, our primary objective is to study the platelet function and the correlation with bleeding phenotype in chronic ITP patients. This might add to platelet count alone in order to understand which patients are at risk of…
ID
Bron
Verkorte titel
Aandoening
chronic ITP
platelet function
Immune thrombocytopenia
fatigue
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To assess platelet function and coagulation parameters in adult chronic ITP patients in relation to their bleeding phenotype
Achtergrond van het onderzoek
In the current proposal, our primary objective is to study the platelet function and the correlation with bleeding phenotype in chronic ITP patients. This might add to platelet count alone in order to understand which patients are at risk of significant bleeding or need treatment. Secondary, we will assess imbalances in the patients’ immunologic profiles in patients with chronic ITP, the extent of fatigue and menstrual problems and the internal consistency of the fatigue subscale of the CIS-20. These results will increase insight in which areas are feasible for future (interventional) research.
Doel van het onderzoek
In the current proposal, our primary objective is to study the platelet function and the correlation with bleeding phenotype in chronic ITP patients. This might add to platelet count alone in order to understand which patients are at risk of significant bleeding or need treatment. Secondary, we will assess imbalances in the patients’ immunologic profiles in patients with chronic ITP, the extent of fatigue and menstrual problems and the internal consistency of the fatigue subscale of the CIS-20. These results will increase insight in which areas are feasible for future (interventional) research.
Onderzoeksopzet
1 timepoint (cross-sectional study)
Onderzoeksproduct en/of interventie
An extra blood sample withdrawal during a routine venipuncture (as part of standard of care), the ITP-bleeding assessment tool (ITP-BAT) and two questionnaires. Women will be asked to fill out an extra questionnaire regarding their menstruation and to count the use of sanitary pads and/or tampons during one month (PBAC).
Algemeen / deelnemers
Wobke Dijk, van
Postbus 85500
Utrecht 3508 GA
The Netherlands
0887567846
W.E.M.vanDijk-16@umcutrecht.nl
Wetenschappers
Wobke Dijk, van
Postbus 85500
Utrecht 3508 GA
The Netherlands
0887567846
W.E.M.vanDijk-16@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
-Age 16 years and older
-Previously confirmed diagnosis of chronic primary ITP with current platelet counts of <100x109/L or currently on (any) treatment for chronic ITP
-Willing and able to understand the study information and sign the informed consent form.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
There are no additional exclusion criteria
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7200 |
| NTR-old | NTR7399 |
| CCMO | NL66313.041.18 |
| OMON | NL-OMON52965 |