We hypothesize that in pre-diabetic participants (impaired fasting glucose, IFG and/or impaired glucose tolerance, IGT), passive mild heat acclimation (35˚C) will improve insulin signalling and affect heat shock protein 72 expression, which…
ID
Bron
Verkorte titel
Aandoening
Prediabetes
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
o Insulin sensitivity as measured by a 1-step hyperinsulinemic euglycemic clamp<br>
o Insulin signalling and heat shock protein expression in muscle tissue
Doel van het onderzoek
We hypothesize that in pre-diabetic participants (impaired fasting glucose, IFG and/or impaired glucose tolerance, IGT), passive mild heat acclimation (35˚C) will improve insulin signalling and affect heat shock protein 72 expression, which might be involved in the changes in insulin resistance. We furthermore hypothesize that passive mild heat acclimation will alter thermophysiological parameters (energy expenditure, total sweat loss, sweat rate, core body temperature, skin temperature distribution, skin blood flow), cardiovascular parameters and subjective perception of the thermal environment in pre-diabetic participants.
Onderzoeksopzet
pre and post intervention (days 1, 2 11 and 12)
Onderzoeksproduct en/of interventie
The intervention consists of 10 days (2 half days and 8 full days) of passive mild heat acclimation to 35˚C.
Algemeen / deelnemers
Wouter Marken Lichtenbelt, van
P.O. Box 616
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881629
markenlichtenbelt@maastrichtuniversity.nl
Wetenschappers
Wouter Marken Lichtenbelt, van
P.O. Box 616
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881629
markenlichtenbelt@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
o Men
o Caucasian race
o Age 40-70 years
o BMI between 25 and 30 kg/m2
o Steady dietary habits
o Generally healthy, no medication use that interferes with metabolism. If volunteers need medication (e.g. statin drugs, NSAIDs), it will be reviewed with the dependent physician on individual basis.
o Impaired fasting glucose levels between 6.1 and 7.0mmol/L and/or blood glucose values >7.8-11.1mmol/L 2h after sugar drink consumption during OGTT (screening)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
o Fasting plasma glucose >7.0 mmol/L
o Haemoglobin <8.4mmol/L
o No signs of active uncontrolled hypertension, liver of kidney malfunction
o Cardiac problems and cardiovascular diseases, such as angina pectoris, cardiac infarction and arrhythmias
o Any medical condition requiring treatment and/or medication that interferes with investigated parameters. All medical conditions/medications will be reviewed with the dependent physician and in-/exclusion will be decided on individual basis
o Unstable body weight (weight gain or loss >3kg in the past three months)
o Participation in another biomedical study within 1 month prior to screening visit
o Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
o Blood donation three month prior to study and three month after finishing study
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5590 |
| NTR-old | NTR5696 |
| CCMO | NL56876.068.16 |
| OMON | NL-OMON43282 |