We hypothesize that the brain dopamine system plays a role in subjective probability processing and we hypothesize that both the brain dopamine and noradrenaline system play a role in subjective value processing.
ID
Bron
Aandoening
dopamine antagonism, noradrenaline antagonism, subjective probability processing, subjective value processing, dopamine antagonisme, noradrenaline antagonisme, subjectieve waardevolheid, subjectieve waarschijnlijkheid.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Cue specific P200 event-related potential relative to no cue, cue specific P300 event-related potential relative to no cue. Independent variables: Subjective value, Subjective probability, dopaminergic antagonism by haloperidol and noradrenergic antagonism by clonidine.
Doel van het onderzoek
We hypothesize that the brain dopamine system plays a role in subjective probability processing and we hypothesize that both the brain dopamine and noradrenaline system play a role in subjective value processing.
Onderzoeksopzet
Participants will be tested during 3 separate sessions.
Measurements will be made 3 hours after capsule intake.
Onderzoeksproduct en/of interventie
- one capsule containing 150 microgram clonidine
- one capsule containing 2 milligram haloperidol
- one capsule containing placebo
Algemeen / deelnemers
Iris Schutte
Heidelberglaan 2
Utrecht 3584 CS
The Netherlands
+31 30 2534368
i.schutte@uu.nl
Wetenschappers
Iris Schutte
Heidelberglaan 2
Utrecht 3584 CS
The Netherlands
+31 30 2534368
i.schutte@uu.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Male, non-smoking, age between 18-45 years and passing the screening (assessing medical history and blood pressure/heart rate)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Psychopathology, current medication use, (history of) serious medical condition(s), low blood pressure, heart rate above 100 bpm or below 60 bpm in rest.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4917 |
| NTR-old | NTR5019 |
| CCMO | NL51144.041.14 |
| OMON | NL-OMON44020 |