Measurement of changes in ventilation at various levels of inspired carbon dioxide with two methodes.

Effects of increasing/decreasing levels of CO2 on ventilation can be studied using the hypercapnic ventilatory response (HCVR). In various patient groups the HCVR is disturbed. Two methods are known to measure the HCVR, the rebreathing and steady-state method. Both methods can measure the ventilation response to CO2, therefore in this study the two methods will be compared. Computer controlled systems are not available for use, due to high costs to persuade or built them. In this study two self-made apparatuses are built, based on literature. The aim of the study is to find out which method is to be implemented in the clinic, as a diagnostic tool, on basis of the repeatability of both tests.

The primary objective is to investigate whether the rebreathing apparatus or the steady-state apparatus should be used as a diagnostic tool in the MST. The primary objective is answer by means of sub questions, which involve; the repeatability of both methods, experiences of the subjects, costs and time duration of both methods.

Measurements are performed with 20 subjects. Two appointments per subject are made, the second measurement is within 5-9 days after the first. At both appointments HCVR is measured with both methods. At the first appointment the order is determined with a randomisation list (rebreathing steady-state or steady-state rebreathing).

not applicable