IgG4-associated cholangitis mimicks perihilar cholangiocarcinoma, resulying in patients being resected for benign disease
ID
Bron
Aandoening
IgG4-associated cholangitis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Incidence of IgG4-associated cholangitis in patients resected for presumed PHC
Achtergrond van het onderzoek
Our aim is to assess the incidence of Immunoglobulin G4-associated cholangitis (IAC) in patients resected for presumed perihilar cholangiocarcinoma (PHC). All patients that underwent resection for presumed PHC at our institution between 1984 and 2015 were included. Benign histological specimens were re-evaluated by a pathologist and scored according to the international pathological consensus criteria for IgG4-RD. Patients with benign disease who were still alive were re-evaluated to assess IgG4 serum levels and IgG4/IgG RNA ratio to detect activity of IAC.
Doel van het onderzoek
IgG4-associated cholangitis mimicks perihilar cholangiocarcinoma, resulying in patients being resected for benign disease
Onderzoeksopzet
-re-evaluation resection specimens
-clinical re-evaluation symptoms and serummarkers
Onderzoeksproduct en/of interventie
None
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Resection for presumed perihilar cholangiocarcinoma
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
none
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6287 |
| NTR-old | NTR6461 |
| CCMO | NL58029.018.16 |
| OMON | NL-OMON42948 |