The use of the laparoscopic insertion technique will lower the proportion of malfunctioning PD-catheters.
ID
Bron
Verkorte titel
Aandoening
End-stage renal disease
Peritoneal dialysis
Laparoscopy
Open
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Percentage of functioning catheters at 6 weeks postoperatively.
Achtergrond van het onderzoek
Almost 15.000 Dutch patients with end-stage renal disease (ESRD) are dependent of renal replacement therapy (RRT; dialysis and transplantation). Of the nearly 6300 patients on dialysis, one fifth is on continuous ambulant peritoneal dialysis (CAPD). It has an advantage over haemodialysis in that it allows patients greater freedom to perform daily activities; it also provides other clinical benefits, such as less dietary and fluid restriction, better blood pressure control and less cardiovascular stress. Another advantage of CAPD over haemodialysis is the costs. Annually, CAPD costs $43,000 dollars less than haemodialysis, therefore well-functioning CAPD has major economic consequences. The key to successful CAPD is the presence of a well-functioning dialysis catheter, defined as one that facilitates free dialysis solution inflow and outflow. However, we have noticed that CAPD catheter insertion has a high rate of technical failure using the standard open technique and thus needs improvement. The current literature describes a range from 10-35 % catheter failure with the open technique. Catheter malfunction is most commonly caused by mechanical complications, such as kinking or malpositioning of the catheter tip. Complications frequently cause considerable problems for ESRD patients, including re-operation and an increased risk of losing access to CAPD. For a small but significant number of patients this leads to severe morbidity and even mortality. Laparoscopic procedures have proven to be superior to a number of open surgical procedures, by reducing morbidity, length of hospital stay, postoperative pain and lead to a quicker convalescence. In contrast to the open technique, laparoscopic insertion enables the surgeon to insert the CAPD-catheter under direct vision using a video-laparoscope, and thus enables him to ascertain the correct catheter position at the end of the operation. In current literature, comparative trials show no significant difference in the risk of catheter removal, replacement or technical failure between both techniques, however there are no well-designed randomized controlled trial comparing laparoscopic CAPD-catheter insertion to the traditional open technique.
Doel van het onderzoek
The use of the laparoscopic insertion technique will lower the proportion of malfunctioning PD-catheters.
Onderzoeksopzet
1. Baseline;
2. 6 weeks;
3. 6 months.
Onderzoeksproduct en/of interventie
1. Laparoscopic PD catheter insertion;
2. Open PD catheter insertion.
Publiek
S.M. Hagen
Erasmus MC, Rotterdam
Afdeling Heelkunde, H-822k
Rotterdam 3000 CA
The Netherlands
s.hagen@erasmusmc.nl
Wetenschappelijk
S.M. Hagen
Erasmus MC, Rotterdam
Afdeling Heelkunde, H-822k
Rotterdam 3000 CA
The Netherlands
s.hagen@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. All patients with an indication for peritoneal dialysis;
2. 18 years and older.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. BMI >35 kg/m2;
2. Severe COPD (or otherwise not able to withstand laparoscopic surgery);
3. Age <18 years.
Opzet
Deelname
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