In comparison to placebo (PLC), atomoxetine (ATX) alters specific components of brain networks underlying cognition and reward-related networks and modulates task performance.
ID
Bron
Verkorte titel
Aandoening
Psychiatric illness; ADHD; depression; schizophrenia; cognitive abilities; attention; executive functions; reward learning
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Performance on neuropsychological tests and associated brain activity (MRI)
Doel van het onderzoek
In comparison to placebo (PLC), atomoxetine (ATX) alters specific components of brain networks underlying cognition and reward-related networks and modulates task performance.
Onderzoeksopzet
3 timepoints. Session 1 (Day 1), Session 2 (Day 4), session 3 (Day 11).
Onderzoeksproduct en/of interventie
The study consists of three sessions.
Session 1: In a 1-hour session, we will measure mood variables and executive functions.
Session 2 and 3:We will measure attention-related skills and related brain activity with neuropsychological tasks and MRI. On one occasion, the participant receives a placebo (a fake pill) and on the other occasion atomoxetine 60mg (oral; a safe challenge that temporarily increases noradrenaline and dopamine in the brain).
Publiek
Dennis Hernaus
Vijverdalseweg 1 (2e verdieping SN gebouw)
Maastricht 6226NB
The Netherlands
T +31 43 388 3896
strax@maastrichtuniversity.nl
Wetenschappelijk
Dennis Hernaus
Vijverdalseweg 1 (2e verdieping SN gebouw)
Maastricht 6226NB
The Netherlands
T +31 43 388 3896
strax@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Male gender
- Age between 18 and 30
- Right-handed
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Psychiatric disorders
- Neurological disorders
- Endocrine disorders
- Drug or alcohol dependence
- Current (recreational) drug use; will be checked in urine
- Recent use of corticosteroids
- Past/current psychopharmacological treatment (e.g. antidepressants, antipsychotics, mood stabilisers, sleeping medication)
- High (>28) or low (<18) Body-Mass Index
- Contraindication for a magnetic resonance imaging (MRI) scan
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5558 |
| NTR-old | NTR5679 |
| CCMO | NL53913.068.15 |
| OMON | NL-OMON43560 |