The hypothesis is that poststroke fatigue is associated with pituitary dysfunction. Other factors associated with poststroke fatigue, e.g. sleep apnoea and laboratory dysfunction, will be investigated as well.
ID
Bron
Verkorte titel
Aandoening
ischemic stroke
fatigue
pituitary dysfunction
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To assess the difference in prevalence of pituitary dysfunction between patients with and patients without fatigue after ischemic stroke.
Doel van het onderzoek
The hypothesis is that poststroke fatigue is associated with pituitary dysfunction.
Other factors associated with poststroke fatigue, e.g. sleep apnoea and laboratory dysfunction, will be investigated as well.
Onderzoeksopzet
Patients will be assessed at enrolment, and at 3 months, 6 months and 12 months thereafter.
Onderzoeksproduct en/of interventie
Besides standard treatment at enrolment, patients will undergo a general physical examination, a questionnaire, a cognitive performance test, a polygraph, a standardized fasting blood test and a routine hormone screening protocol. In case of abnormal hormonal values, additional tests will be performed to assess the level of dysfunction.
Publiek
Department of Intensive Care
P.O. Box 7057
A. Beishuizen
Clinical research, Intensive Care
Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
+31(0)20 444444492
beishuizen@vumc.nl
Wetenschappelijk
Department of Intensive Care
P.O. Box 7057
A. Beishuizen
Clinical research, Intensive Care
Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
+31(0)20 444444492
beishuizen@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
A subject must meet all of the following criteria:
- 18 years or older;
- NIHSS score12 of ¡Ý 2;
- be expected to be discharged to a rehabilitation unit or to home.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients will be excluded when they:
- are being treated with chemotherapeutics;
- are receiving (oral or intravenous) corticosteroid therapy for more than 1 month (not: inhalation corticosteroids);
- are pregnant;
- are not able to complete a questionnaire due to severe aphasia, non-Dutch speaking or severe cognitive disturbances;
- have a history of hypothalamic/pituitary disease that significantly affects the study results, e.g. Cushing¡¯s disease, cranial irradiation or another significant intracranial lesion, multiple sclerosis, chronic fatigue syndrome and/or psychiatric condition that interferes with interpretation of the study.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5182 |
| NTR-old | NTR5330 |
| CCMO | NL52674.044.15 |
| OMON | NL-OMON47027 |