The molecular detection of the bacterial load is useful for diagnostics and therapeutic monitoring in patients with (suspected) bacterial endocarditis.
ID
Bron
Verkorte titel
Aandoening
endocarditis
diagnosis and monitoring of endocarditis
molecular diagnostics
bacterial load
real time pcr
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Determination of the diagnostic value of mBL for the diagnosis of bacterial endocarditis with endocarditis defined according to Duke criteria;<br>
2. Prognostic value of mBL in patients with endocarditis according to Duke criteria with regard to the occurrence of a complicated course;<br>
3. A descriptive model of the kinetics of mBL related to infectious parameters (CRP, WBC, PCT) in patients with an uncomplicated treatment course of bacterial endocarditis.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
The molecular detection of the bacterial load is useful for diagnostics and therapeutic monitoring in patients with (suspected) bacterial endocarditis.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
No interventions; observational study.
Publiek
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Wetenschappelijk
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Adult patients (≥18 years) with suspected endocarditis, admitted in one of the participating hospitals;
2. Written informed consent is obtained.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Failure to obtain written informed consent to participate;
2. Endocarditis caused by Coxiella burnetii (Q-fever);
3. An Hb below 5.0 mmol/L;
4. Death before first sample is obtained.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2790 |
| NTR-old | NTR2930 |
| CCMO | NL35425.029.11 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON35768 |