Possible predictive factors for sarcopenia (primary outcome) could be: 1. The length and part of the resected small intestine, 2. Adjuvant (and type of) chemotherapy postoperatively, 3. Complications (like sepsis), 4. Nutritional intake (Energy and…
ID
Bron
Verkorte titel
Aandoening
Patients diagnosed with abdominal cancer and treated with cytoreductive surgery (CRS) and a hyperthermic intraperitoneal chemotherapy (HIPEC) procedure
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Sarcopenia defined as the degenerative loss of skeletal muscle mass that can be quantified by the CT measurement of the psoas muscle surface, normalized for patient height [cm2 m−2].
Achtergrond van het onderzoek
In this explorative observational study we will study the predictive factors for sarcopenia and malabsorption in patients with abdominal cancer undergoing cytoreductive surgery (CRS) combined with hyperthermal intraperitoneal chemotherapy
Doel van het onderzoek
Possible predictive factors for sarcopenia (primary outcome) could be: 1. The length and part of the resected small intestine, 2. Adjuvant (and type of) chemotherapy postoperatively, 3. Complications (like sepsis), 4. Nutritional intake (Energy and protein), 5. Preoperative muscle loss (sarcopenia), 6. Movement.
Possible predictive factors for malabsorption (secondary outcome) could be 1. The length and part of the resected small intestine 2. Adjuvant (and type of) chemotherapy postoperatively 3. Small intestinal bacterial overgrowth, especially when the ileocecal valve dysfunctions
Onderzoeksopzet
Sarcopenia will be measured before surgery and 12 months after surgery.
The other endpoints will be registered at 3 and 6 months after surgery as well
Onderzoeksproduct en/of interventie
None, this is an explorative observational trial
Publiek
Marjo Campmans-Kuijpers
Postbus 30.001
Groningen 9700RB
The Netherlands
06-55256587
M.J.E.Campmans-Kuijpers@UMCG.nl
Wetenschappelijk
Marjo Campmans-Kuijpers
Postbus 30.001
Groningen 9700RB
The Netherlands
06-55256587
M.J.E.Campmans-Kuijpers@UMCG.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Patients that undergo CRS and HIPEC procedure at the University Medical Center Groningen (UMCG)
• Written informed consent
• Age > 18 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
• Not fit for surgery
• Inability to provide written consent or inability to fill out questionnaires
• Karnofsky Performance Status < 80
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5961 |
| NTR-old | NTR6327 |
| CCMO | NL57812.042.16 |
| OMON | NL-OMON42927 |