The primary objective of this pilot study is to calculate the sensitivity and specificity for discriminating tumor and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements. The secondary objective of this…
ID
Bron
Aandoening
colorectal cancer
Ondersteuning
Grant from KWF
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Calculation of the sensitivity and specificity for discriminating tumor and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements.
Achtergrond van het onderzoek
Subjects recruited at Nederlands Kanker Instituut (NKI) in Amsterdam. Single study site.
Optical spectroscopy measurements of normal and malignant colorectal tissue and healthy surrounding tissues are performed during surgery. After surgery, spectroscopic measurements are repeated on the excised tissue. To compare the spectroscopic measurements to standard histopathology assessment, biopsies will be taken from the measured locations on the excised specimen. In vivo biopsies are taken of measurement locations on healthy tissue that cannot be resected with the tumor.
Doel van het onderzoek
The primary objective of this pilot study is to calculate the sensitivity and specificity for discriminating tumor and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements. The secondary objective of this study is to calculate the spectral differences between in vivo and ex vivo measurements and the difference in the biological parameters (i.e. blood, water and fat content and blood oxygenation) that are extracted from the spectral information.
Onderzoeksopzet
Only one measurement at day of surgery.
Onderzoeksproduct en/of interventie
Observation of surgical tissue by means of optical spectroscopy.
Publiek
Celine Reverseau
Eindhoven 5656 AE
The Netherlands
+31631639778
celine.reverseau@philips.com
Wetenschappelijk
Celine Reverseau
Eindhoven 5656 AE
The Netherlands
+31631639778
celine.reverseau@philips.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
-Patients planned for elective colorectal surgery for either primary or recurrent colorectal cancer by an open or laparoscopic approach
- Patients planned for a HIPEC procedure for colorectal cancer
- Patients that have provided a signed informed consent
- Patients ¡Ý 18 years old
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients with suspected sensitivity to light; e.g. patients who have had photodynamic therapy
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5175 |
| NTR-old | NTR5315 |
| CCMO | NL48298.031.14 |
| OMON | NL-OMON47243 |