Lithium trial bij ALS

1. Definite, probable, or probable-laboratory supported ALS according to the revised El Escorial World Federation of Neurology criteria.

2. Intake of riluzole 2dd 50 mg

3. A disease duration (at inclusion) of more than 6 months and less than 36 months

4. Vital capacity (VC%) ¡Ý 70 % of normal value

5. Age 18 - 85 years

6. Capable of thoroughly understanding the trial information given; has signed the informed consent.

1. Tracheostomy, tracheostomal ventilation of any type, non-invasive ventilation more than 16 hours/ day, or supplemental oxygen during the last three months prior to inclusion.

2. Any medical condition or intoxication known to have an association with motor neuron dysfunction, which might confound or obscure the diagnosis of ALS.

3. Presence of any concomitant life-threatening disease or any disease or impairment likely to interfere with functional assessment.

4. Contra indications for lithium therapy

5. Interaction of lithium with other medication