In normal weight and overweight/obese young males we expect that - when compared to a single bout of prolonged sitting: (1) sitting on a stability ball will attenuate cardiometabolic health effects; (2) 10-min standing interruptions will not…
ID
Bron
Verkorte titel
Aandoening
ENGLISH:
Recent experimental studies on the acute effects of prolonged sitting demonstrated that interruptions during prolonged sitting significantly reduced postprandial glucose, insulin and C-peptide in healthy young adults. Sitting on a stability ball and 10-min standing interruptions may attenuate these negative health effects of prolonged sitting. DUTCH: Recentelijk is aangetoond dat het onderbreken van aaneengesloten zitten een positief effect heeft op postprandiale (d.w.z. na een maaltijd) waarden van glucose, insuline en C-peptide in het bloed. Het is nog onbekend of het actief zitten op een stabiliteitsbal of 10-min durende sta-onderbrekingen de negatieve effecten van aaneengesloten zitten kunnen onderbreken.
Ondersteuning
VU University Medical Center (VUmc)
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main outcomes of this study are plasma levels of C-peptide, glucose, triglycerides, high-sensitive C-reactive protein (hs-CRP) and saliva levels of cortisol.
Doel van het onderzoek
In normal weight and overweight/obese young males we expect that - when compared to a single bout of prolonged sitting:
(1) sitting on a stability ball will attenuate cardiometabolic health effects;
(2) 10-min standing interruptions will not attenuate cardiometabolic health effects.
Onderzoeksopzet
Plasma levels of C-peptide, glucose, triglycerides, hs-CRP will be collected hourly (i.e. 6 blood samples); saliva will be collected at baseline and at the end of the experimental days.
Onderzoeksproduct en/of interventie
All included young males will undergo three experimental conditions, with a one-week washout period in between conditions:
I. Sitting only (i.e. on a chair with back support; control condition): participants will remain seated for 5 consecutive hours;
II. Sitting (on a chair with back support) and hourly 10-min standing interruptions: participants will stand for 10-min, using a sit-stand desk before returning to the seated position for 50 minutes. This procedure will be repeated 4 times (i.e. first hour is included to obtain a steady-state, with no standing interruption);
III. Sitting on a stability ball (i.e. without back support): participants will sit on a stability ball (i.e. without back support) for 5 consecutive hours.
Publiek
Teatske Altenburg
van der Boechorststraat 7, room MF-C575
Amsterdam 1081 BT
The Netherlands
020-4441736
t.altenburg@vumc.nl
Wetenschappelijk
Teatske Altenburg
van der Boechorststraat 7, room MF-C575
Amsterdam 1081 BT
The Netherlands
020-4441736
t.altenburg@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Apparently healthy normal weight or overweight/obese males;
- Aged 18-20 years;
- Dutch or English speaking;
- Signed informed consent from the participant (age 18-19) or the participant and both parents (age 17).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Major acute illness/injury;
- Having diabetes mellitus type II – according to the International Diabetes Federation;
- Physical problems that may limit the ability to perform the experiment (i.e. the standing interruptions or sitting on a stability ball).
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5616 |
| NTR-old | NTR5723 |
| CCMO | NL51407.029.15 |
| OMON | NL-OMON44870 |