Comparison of CT-angiography and Transcranial doppler for the detection of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
ID
Bron
Verkorte titel
Aandoening
Subarachnoid hemorrhage. Cerebral vasospasm
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Sensitivity and specificity.
Achtergrond van het onderzoek
This study is an observation pilot study in which prospectively consecutive patients with a subarachnoid hemorrhage are included. All patients are screened with TCD 2-3 times a week for vasospasm, according to the local management guidelines. Besides TCD, a CT-A scans are made for each patient on day 5 and 10 and in case of clinical deterioration. The results of TCD and CTA are compared and linked to clinical symptoms. In case of clinically symptomatic vasospasm, patients are treated according to a pre-defined protocol which is documenten in the local management guidelines. After finishing the pilot studies, we are planning to set-up a large scale cost-effectiveness study in order to investigate which method is most efficient.
Doel van het onderzoek
Comparison of CT-angiography and Transcranial doppler for the detection of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Onderzoeksopzet
TCD 3 times a week
CTA on day 5 and 10 (+/- 1 day)
Onderzoeksproduct en/of interventie
Comparison of CT angiography and Transcranial doppler in the detection of cerebral vasospasm after subarachnoid hemorrhage.
Publiek
University Medical Center Groningen
Hanzeplein 1
M. Uyttenboogaart
Groningen 9713 GZ
The Netherlands
+31-50-3612400
M.uyttenboogaart@umcg.nl
Wetenschappelijk
University Medical Center Groningen
Hanzeplein 1
M. Uyttenboogaart
Groningen 9713 GZ
The Netherlands
+31-50-3612400
M.uyttenboogaart@umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Aneurysmal subarachnoid hemorrhage
Age 18 years or older
Inclusion within 4 days after onset
Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Very poor prognosis
Renal insufficiency (eGFR < 60 ml/min/1.73m2)
Treatment with metformine
Inability to perform TCD (temporal bone window)
Contraindication for iodinated contrast agent (allergy, m. Kahler, myasthenia gravis, pheochromocytoma, mastocytosis, thyroid cancer, nuclear thyroid scan)
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3985 |
| NTR-old | NTR4157 |
| CCMO | NL41458.042.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON40069 |