The main hypothesis is that compared to TAU, BA will be more effective and less costly. A secondary goal is to explore several potential mechanisms of change, as well as predictors and moderators of treatment outcome of BA for late-life depression.
ID
Bron
Verkorte titel
Aandoening
Late-life depression, depressive symptoms, depressie, depressieve symptomen, depressieve klachten, elderly.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Depression severity as assessed with the Quick Inventory of Depressive Symptomatology (Q-IDS) during the 8-week treatment period and follow-up.
Achtergrond van het onderzoek
With 12-25% prevalence, clinically significant depression is common in later life. However, the efficacy of current pharmacological and psychological treatments is limited. Behavioural programmes for late-life depression have recently received renewed attention with findings suggesting that Behavioural Activation (BA) may be effective. The primary objective of this study is to compare the effectiveness and cost-effectiveness of behavioural activation (BA) and treatment as usual (TAU) for late-life depression in primary care in the Netherlands. A cluster-randomised and controlled multicentre trial (RCT) is conducted, with two parallel groups: a) Behavioural activation, and b) Treatment as usual, conducted in primary care centres (PCC) with a follow-up of 52 weeks (FU).
Doel van het onderzoek
The main hypothesis is that compared to TAU, BA will be more effective and less costly. A secondary goal is to explore several potential mechanisms of change, as well as predictors and moderators of treatment outcome of BA for late-life depression.
Onderzoeksopzet
Participants in both the BA- and TAU-condition will complete these measures every two to three weeks during the 8 week therapy period, at post-treatment, and every three months during the 52-week follow-up.
Onderzoeksproduct en/of interventie
In behavioural activation (BA) patients are encouraged to increase their activity levels, engage in more reinforcing and pleasurable activities, and modify avoidance and withdrawal patterns. BA is a component of cognitive-behavioural therapy (CBT), a more complex approach targeting both thoughts and behaviours.
Publiek
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
Wetenschappelijk
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
The main inclusion criterion is a PHQ-9 score >9.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients will be excluded from the trial in the case of I) severe mental illness in need of specialized treatment, including severe major depression, bipolar disorder, obsessive-compulsive disorder, (history of) psychosis; II) high risk of suicide, III) drug and/or alcohol abuse or dependence, IV) prior psychotherapy received in the previous 12 weeks V) current treatment by a mental health specialist. VI) moderate to severe cognitive impairment (MoCA <18).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5436 |
| NTR-old | NTR6013 |
| CCMO | NL54470.091.16 |
| OMON | NL-OMON47861 |
Samenvatting resultaten
Huibers, M. J., et al. (2014). Predicting response to cognitive therapy and interpersonal therapy, with or without antidepressant medication, for major depression: a pragmatic trial in routine practice. J Affect Disord, 152-154, 146-154.
<br><br>
Lemmens, L. H., Arntz, A., Peeters, F., Hollon, S. D., Roefs, A. and Huibers, M. J. (2015). Clinical effectiveness of cognitive therapy v. interpersonal psychotherapy for depression: results of a randomized controlled trial. Psychol Med, 1-16.<br><br>
Licht-Strunk, E., Van Marwijk, H. W., Hoekstra, T., Twisk, J. W., De Haan, M. and Beekman, A. T. (2009). Outcome of depression in later life in primary care: longitudinal cohort study with three years' follow-up. BMJ, 338, a3079.