The q-sense device will induce an equal conditioned pain modulation effect as the standard conditioning stimulus: cold water immersion. Ipsilateral and contralateral conditioning will elicit equal conditioning pain modulation effects.
ID
Bron
Verkorte titel
Aandoening
neuropathic pain; CPM; conditioned pain modulation; chronic pain; healthy subjects; endogenous analgesia; descending inhibition. neuropatische pijn; CPM; chronische pijn; gezonde vrijwilligers; endogene pijnstilling
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The degree of CPM of q-sense vs cold water immersion:
CPM is defined as the difference in pain intensity scored by the subject on a electronic visual analogue scale (eVAS) between non-conditioned and conditioned stimuli. We will evaluate the difference between CPM by the q-sense and CPM by cold water immersion.
Achtergrond van het onderzoek
Conditioned pain modulation (CPM) is form of endogenous analgesia that is decreased in patients with chronic pain. The CPM paradigm is often used in experiments to determine whether endogenous analgesia of a group of patients is different from healthy subjects. However, the methods used differs between research groups. The q-sense device has been developed to measure CPM by using a thermal conditioning probe and to be able to compare studies. We will compare the ability of the q-sense to induce CPM with the most commonly used method to induce CPM so far: cold water immersion. Furthermore, we will compare ipsilateral with contralateral conditioning.
Doel van het onderzoek
The q-sense device will induce an equal conditioned pain modulation effect as the standard conditioning stimulus: cold water immersion.
Ipsilateral and contralateral conditioning will elicit equal conditioning pain modulation effects.
Onderzoeksopzet
n.a.
Onderzoeksproduct en/of interventie
Thermal pain testing using the conditioned pain modulation (CPM) paradigm:
1)using the q-sense
2)using water of 6 degrees Celsius
Publiek
P5-46<br>
Albinusdreef 2
L.C.J. Oudejans
Leiden 2333 ZA
The Netherlands
+31 (0)71 5262301
L.C.J.Oudejans@lumc.nl
Wetenschappelijk
P5-46<br>
Albinusdreef 2
L.C.J. Oudejans
Leiden 2333 ZA
The Netherlands
+31 (0)71 5262301
L.C.J.Oudejans@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy male volunteers, aged 18 - 35, right handed.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Obesity (BMI > 30 kg/m2);
History of chronic alcohol or illicit drug use;
History of illness, condition or medication use that, in the opinion of the investigator, might interfere with participation, or could confound the result;
Inability to understand the study information or give oral and written consent.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5305 |
| NTR-old | NTR5414 |
| CCMO | NL53726.058.15 |
| OMON | NL-OMON42364 |