Pharmacokinetic modelling of ropivacain in plastic surgery

Background:
In plastic surgery of the MMC, the emphasis is on the use of local anesthetics to minimize the postoperative pain. The effective control of postoperative pain is not only very desirable for humanitarian reasons, it is more often that this provides significant physiological benefits.

With reducing post operative pain, is postoperative recovery faster, minimize clinical stay and return faster to work.
About the absorption of ropivacaine and serum concentration is limited evidence. That is why we want to study the serum concentration of local infiltrated ropivacaïne in venous blood.



Methods:
For this study will thirty healthy patients older than 18 years who are undergoing breastreduction, abdominoplastic and endoscopic browlift in Maxima Medisch Centrum. Exclusion criteria included contraindications for regional anesthesia, hypersensitivity for ropivacaine and any know heptic and/or renal failure.

To determine the resorption of ropivacaïne and serum concentration we will take 6 bloodsamples at t=0, t=30 min, t=1 hour, t=2 hour, t=4 hour, t=8 hour. A pharmacokinetic model for each procedure will be made by using a software package MW/Pharm © (version 3.81).

The serumconcentration of ropivacaïne 10mg/ml are low after local infiltration with the standard dosis.

t=0, t=30 min, t=1 hour, t=2 hour, t=4 hour, t=8 hour

Take 6 bloodsamples after local infiltration with ropivacain.