Estrogen plays an role in the dynamic changes in bone marrow adiposity.
ID
Bron
Verkorte titel
Aandoening
Osteoporosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The role of estrogen in dynamic changes in bone marrow adiposity these changes.
Achtergrond van het onderzoek
Bone marrow consists mainly of bone cells, fat cells and hematopoietic cells. The gradual decrease of bone and hematopoietic fraction and the increase of fat fraction in the bone marrow with ageing and the same rapid changes following menopause have long been recognized. A recent and unexpected observation is that these parameters show dynamic changes over the course of days during a normal menstrual cycle. A common denominator for both phenomena might be estrogen status.
Doel van het onderzoek
Estrogen plays an role in the dynamic changes in bone marrow adiposity.
Onderzoeksopzet
Study duration of 6 weeks, with intervention form day 14 to 28.
MRI to measure BM adiposity and bloodsamples at day 0/7/14/21/28/35/42.
Onderzoeksproduct en/of interventie
Estrogen (Zumenon 1dd 2 mg) day 14 to day 28
Publiek
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
Wetenschappelijk
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Postmenopausal women
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• contraindications to MRI scanning as determined by a standard checklist
• use of bone-modifying or adipose tissue-modifying drugs
• bone/adipose tissue/bone marrow diseases
• contraindications to estrogen treatment (history of hormone-sensitive cancer, VTE, unexplained vaginal bleeding, endometrial hyperplasia, endometriosis, arterial thrombo-embolic diseases, acute hepatic disease or liver enzyme disorders, porfyria or known hypersensitivity to components of zumenon)
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4390 |
| NTR-old | NTR4521 |
| CCMO | NL40171.018.12 |
| OMON | NL-OMON39889 |