Study I: To assess the bioavailability of Zinc from milk (1), fortified milk (2), a supplement (3), and from raw milk (4). Study II: To assess the effect of milk on Zn absorption from intrinsically labelled rice
ID
Bron
Aandoening
bioavailability, biobeschikbaarheid
absorption, absorptie
Ondersteuning
Division of Human Nutrition
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Fractional absorption of Zn, as measured from isotope ratios in urine samples.
Achtergrond van het onderzoek
Zinc deficiency is widespread globally. Some estimates indicate that 20% of the total world population has some degree of zinc deficiency. Zinc is one of the many essential nutrients found in milk. With a concentration of ~0.4 mg Zn per 100 g of milk, it forms an important source of Zn in dairy consuming populations such as in the Netherlands. To our knowledge, information on zinc absorption from regular dairy products and dairy containing meals in human subjects is scarce.
Doel van het onderzoek
Study I: To assess the bioavailability of Zinc from milk (1), fortified milk (2), a supplement (3), and from raw milk (4).
Study II: To assess the effect of milk on Zn absorption from intrinsically labelled rice
Onderzoeksopzet
At all test days urine samples will be collected at baseline and at at 96 ± 3 h after test meal administration.
At all test days blood samples will be collected at baseline.
Onderzoeksproduct en/of interventie
Study I:
Intake of
1. milk
2. Zn-fortified milk
3. water + Zn supplement
4. raw milk
All test meals are extrinsically labelled with 67Zn.
Study II:
Intake of
1. intrinsically 67Zn labelled rice + milk
2. intrinsically 67Zn labelled rice + Zn fortified water
Each meal will contain ~ 4 mg Zn. In between meals, subjects will receive an intravenous dose of 0.2 mg 70Zn, dissolved in 10 mL saline.
Publiek
Bornse Weilanden 9
Esther Boelsma
Wageningen 6708 WG
The Netherlands
+31 317 480309
esther.boelsma@wur.nl
Wetenschappelijk
Bornse Weilanden 9
Esther Boelsma
Wageningen 6708 WG
The Netherlands
+31 317 480309
esther.boelsma@wur.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Female
• Age between 18-30 years of age (boundaries included)
• Body Mass Index (BMI) between 19-25 kg/m2 (boundaries included)
• Body weight between 60-70 kg (boundaries included)
• No mineral and vitamin supplements two weeks prior to the 1st test meal and during the whole duration of the study
• Willing to abstain from blood donation during the study
• Voluntary participation
• Signed informed consent
• Willing to comply with the study procedures
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Any metabolic, gastrointestinal, inflammatory or chronic disease or disorder (such as diabetes, anaemia, hepatitis, hypertension, cancer or cardiovascular diseases; according to the subjects own statement)
• Continuous/long-term medication during the whole study (except for contraceptives)
• Mineral or vitamin supplements during the 2 weeks prior to 1st test meal
• Lactose intolerance
• Alcohol consumption > 21 glasses per week
• Bad venous access
• Reported weight loss or gain of > 2 kg in the last month before screening
• Reported strictly prescribed diet, vegetarian, vegan or macrobiotic
• Smoking
• Pregnant or lactating or the wish to become pregnant in the study period (a pregnancy test will be done at screening)
• Lack of safe contraception
• Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4051 |
| NTR-old | NTR4267 |
| CCMO | NL45256.081.13 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON40513 |