Effects of an intervention with a Paleolithic diet in subjects with the metabolic syndrome (MetS). A pilot-study.

1. Written informed consent;

2. Age ≥ 18 and < 60 years;

3. At least 2 of the following:

A. Central obesity (waist circumference ≥ 102 cm (male) and ≥ 88 cm (female);

B. Elevated triglycerides: TG ≥ 1.7 mmol /l;

C. Reduced HDL cholesterol: HDL-C < 1.0 mmol /l (male) and <1.3 mmol /l (female);

D. Raised blood pressure ≥ 130 /85 mmHg or medication for hypertension;

E. Elevated fasting plasma glucose ≥ 5.6 mmol /l;

F. Willingness not to consume alcohol during the intervention.

1. Diabetes mellitus type 2, cardiovascular diseases, stroke, cancer and psychological disorders;

2. Systolic blood pressure > 180 mmHg;

3. Smoking (within a month prior to the study);

4. 10 years mortality risk caused by cardiovascular disease > 10 % according to NHG-standard M84 Cardiovascular Risk Management (November 2006);

5. Concomitant pharmacological treatment with hypoglycemic agents, insulin, warfarin or oral steroids;

6. Participation in an other clinical trial at the same time or within the previous month prior to enrolment into this study;

7. Pregnancy or lactation;

8. Recent blood donation (within the last 2 months);

9. Severe internal or systemic disease (e.g. cardiac, hepatic, renal diseases);

10. Non –omnivore (e.g. vegan, vegetarian);

11. Unwillingness to eat fish.