Human brown adipose tissue activity will increase after administration of Thyrotropin-Releasing Hormone (TRH).
ID
Bron
Verkorte titel
Aandoening
Overgewicht, Obesity, Brown adipose tissue, Bruin vet
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
After TRH administration, compared to saline administration;<br>
- Degree of BAT activity<br>
- Skin temperature<br>
- Blood pressure and heart rate<br>
- Serum thyroid hormones and noradrenaline and normetanephrine
Achtergrond van het onderzoek
Brown adipose tissue (BAT) is a classic site of non-shivering thermogenesis in most mammals. BAT thermogenesis is controlled via both neuroendocrine and autonomic pathways, and requires both sympathetic stimulation, and hormonal stimulation via thyroid hormone. We hypothesize that brown adipose tissue activity increases after administration of TRH.
Doel van het onderzoek
Human brown adipose tissue activity will increase after administration of Thyrotropin-Releasing Hormone (TRH).
Onderzoeksopzet
The two scans will be separated by at least 7 days and a maximum of 3 weeks.
Onderzoeksproduct en/of interventie
Two 18F-FDG PET-CT scans per patient will be performed of the neck and shoulders to visualize BAT activity. One scan will be performed following intravenous administration of TRH, while the other will be performed following intravenous administration of a saline solution (placebo). During the scans, temperature, heart rate and blood pressure will be monitored continuously. Blood samples for analysis of thyroid hormones will be taken at 7 time points.
Publiek
Charlotte Heinen
Amsterdam
The Netherlands
+31(0)20-566 6642
c.a.heinen@amc.uva.nl
Wetenschappelijk
Charlotte Heinen
Amsterdam
The Netherlands
+31(0)20-566 6642
c.a.heinen@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Male sex
- Age between 30 and 40 years old
- BMI range 19 to 25 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Treated or untreated hypo- or hyperthyroidism
- Renal dysfunction (eGFR >60)
- Use of any medication known to affect thyroid hormone metabolism or the autonomic nervous system
- Any cardiovascular disease
- Recent stay of >2 weeks in the tropics within the last 6 weeks
- The desire to father a child within 1 month
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4993 |
| NTR-old | NTR5512 |
| CCMO | NL45656.018.13 |
| OMON | NL-OMON41582 |