Oral complications of hematopoietic stem cell transplantation

The oral cavity is a common site of acute and long term complications related to hematopoietic stem cell transplantation (HSCT). These complications cause significant morbidity and are associated with decreased quality of life. To date, management strategies for oral complications are mainly palliative and there is a great need for expanding the arsenal of preventative approaches.



Disturbed homeostasis of the oral cavity has been implicated as an important component of the pathogenesis of oral complications. Studies suggest that a less diverse microbiome, salivary output and proteins, and dental health influence the incidence and severity of oral mucositis and graft versus host disease. In addition, oral environment changes associated with graft versus host disease may increase caries risk. The H-OME study will expand the understanding of the role of the oral ecosystem in the onset, progression, and resolvement of these complications related to HSCT. This is attractive since many oral environment factors are modifiable and we anticipate that this knowledge will enable future development of improved and individualized preventative strategies.

The oral environment (e.g., the oral microbiome and salivary proteome) contributes to the risk and severity of developing oral and dental complications (e.g., oral mucositis and oral graft versus host disease and dental diseases)

Before, during and up to 18 months following hematopoietic stem cell transplantation

Not applicable