Follow-up of the FRUIT-RCT, aspirin resistance and cardiovascular risk factors in women after recurrent hypertensive disorders of pregnancy.

The multicenter FRUIT-RCT demonstrated that adding low-molecular-weight heparin (LMWH) to the standard care aspirin, is beneficial in preventing early-onset hypertensive disorders of pregnancy (HD) in women with inheritable thrombophilia. Bujold et al suggested in a letter to the editor, responding to the FRUIT-RCT1 that the effect of LMWH could have been mainly beneficial in the subgroup of women who are resistant to aspirin. To evaluate this potential relationship we perform a two stage experiment: firstly evaluation of aspirin resistance in the non-pregnant FRUIT-RCT, and secondly the evaluation of aspirin resistance during pregnancy and post-puerperium. Furthermore, we want to assess the prevalence of cardiovascular risk factors in women with inheritable thrombophilia and a history of recurrent HD. We want to examine if women with a history of recurrent hypertensive disorder of pregnancy develop cardiovascular risk factors more frequently than women with a history of single HD.

1: aspirin resistance is related to the occurrence of hypertensive disorders of pregnancy.

2: women with a history of recurrent hypertensive disorder of pregnancy develop cardiovascular risk factors more frequently than women with a history of single hypertensive disorder of pregnancy.

Start as soon as possible.

Participants of the previous FRUIT-RCT receive 10 days aspirin.

For the parallel study women need to have an indication for aspirin usage in pregnancy.