We hypothesize that athletes with the most severe coronary atherosclerosis show an exaggerated exercise-induced cardiac biomarker elevation compared to athletes without coronary atherosclerosis.
ID
Bron
Verkorte titel
Aandoening
Coronary atherosclerosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary aim of this explorative study is to compare exercise-induced cardiac
troponin elevations between athletes with different levels of coronary atherosclerosis.
Achtergrond van het onderzoek
In this study we want to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis.
Doel van het onderzoek
We hypothesize that athletes with the
most severe coronary atherosclerosis show an exaggerated exercise-induced cardiac
biomarker elevation compared to athletes without coronary atherosclerosis.
Onderzoeksopzet
Timepoints for blood withdrawal. Baseline (before exercise test), at 30 minutes during exercise and at 0/30/60/120 and 180 minutes after exercise cessation
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Participation in MARC-2 study (so recent information about coronary atherosclerosis
is known).
- Availability of recent (<2 years) contrast enhanced coronary CT-scan data
- Willingness to be approached for participation in future research (as indicated on the
informed consent form of the MARC-2 study)
- Able to perform a ±1.5 hour exercise test on a bicycle
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Unable to give informed consent
- Presence of a stent in any coronary artery or undergone coronary artery bypass
surgery
- Not cleared for exercise training by a cardiologist following the MARC-2 study
coronary CT-scan findings
- Absolute contra-indications for an exercise test (as indicated by the Standard
Operating Procedure guidelines of the department of Physiology)
- Participation in an interventional study targeting cardiovascular health
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8982 |
| CCMO | NL74326.091.20 |
| OMON | NL-OMON49634 |