Background of the study: Neck pain is a major public health problem alleged in its high prevalence, substantial impact on daily life and huge societal costs. Musculoskeletal Physiotherapy (MP) is an effective treatment for patients with persistent…
ID
Bron
Verkorte titel
Aandoening
Non-specific neck pain
Patients with cervical radiculopathy
Immune system
Cytokine
Chronic pain
Microglia
Physiotherapy
Manual Therapy
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcomes are the short-term (i.e., immediately and two-hours following the intervention) differences in interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) following in-vitro stimulation of whole blood cells.
Achtergrond van het onderzoek
Neck pain is a major public health problem alleged in its high prevalence, substantial impact on daily life and huge societal costs. Musculoskeletal Physiotherapy (MP) is an effective treatment for patients with persistent non-specific neck pain and cervical radiculopathy for reducing pain intensity. The effects of MP are often immediately noticeable after treatment. However, it is currently unknown which working mechanism might cause these effects. In persistent neck pain patients, the immune response - cytokines concentration - identified through whole blood lipopolysaccharide stimulation is elevated compared to healthy control. MP is able to attenuate the in vitro immune response in healthy volunteers. Thereby, a potential mechanism of MP might be attenuation of the immune response.
Doel van het onderzoek
Background of the study: Neck pain is a major public health problem alleged in its high prevalence, substantial impact on daily life and huge societal costs. Musculoskeletal Physiotherapy (MP) is an effective treatment for patients with persistent non-specific neck pain and cervical radiculopathy for reducing pain intensity. The effects of MP are often immediately noticeable after treatment. However, it is currently unknown which working mechanism might cause these effects. In persistent neck pain patients, the immune response - cytokines concentration - identified through whole blood lipopolysaccharide stimulation is elevated compared to healthy control. MP is able to attenuate the in vitro immune response in healthy volunteers. Thereby, a potential mechanism of MP might be attenuation of the immune response. Therefore, the overall aim of this study is to gain insight into the immune response in patients with neck pain and the influence of MP on this immune response in neck pain patients.
Onderzoeksopzet
Three time moments: baseline, immediate post-treatment, 120 minutes post-treatment
Onderzoeksproduct en/of interventie
Patients with non-specific neck pain in study 2 who are allocated to the intervention group will receive a single highvelocity low-amplitude distraction manipulation at the cervico-thoracic region (C7-T4) and a low-velocity low-amplitude cervical mobilization at all of the restricted/painfull cervical segments (C0-C7).
The sham treated patients receive the same treatment position but without the thrust.
Publiek
G.G.M. Scholten-Peeters
Van der Boechorsstraat 9
Amsterdam 1081 BT
The Netherlands
0031683995807
g.g.m.scholten-peeters@vu.nl
Wetenschappelijk
G.G.M. Scholten-Peeters
Van der Boechorsstraat 9
Amsterdam 1081 BT
The Netherlands
0031683995807
g.g.m.scholten-peeters@vu.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Persistent non-specific neck pain
Inclusion:
• Age between 18-65 years.
• Minimal score of 40 on the Visual Pain Anaolgue Scale.
• Persistent pain is defined as pain complaints longer than 6 weeks.
• Can be classified as grade 1 or 2 non-specific neck pain.
• Written informed consent of the subject.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Persistent non-specific neck pain
A potential subject who meets any of the following criteria will be excluded from participation in this study:
• Pregnancy or postpartum for 9 months • Contra-indications for phlebotomy (e.g. phlebitis) • Underwent treatment for current complaints for the last 6 weeks (e.g. physiotherapy, manual therapy, GP etc.) • Having diagnosed mental health disorders (e.g. depression) • Taken one of the following medication for the last 6 weeks: corticosteroids (e.g. prednisone), immunomodulatory medication (e.g. methotrexate, infliximab etc.) and the use of botox for the last 3 months. • Taken one of the following medication: NSAID’s (e.g. diclofenac, ibuprofen, naproxen etc.), Aspirin, Simvastatin (58) for the last two weeks. • Long distance flight (within 7 days), ongoing shift work and hippocampal damage. • Having one of the following medical diseases o Neurological disorders (e.g. MS, myelopathie, cervical stenosis etc.) o Traumatic disorders (e.g. cervical fracture, surgery in the neck area etc.) o Having a history of malignity o Rheumatic or inflammatory disorders (e.g. Spondylitis Ankylpoetica, Crohn disease, sarcoidosis, colitis ulcerous, rheumatic arthritis, COPD, spastic colon, psoriasis etc.) o Cardiac diseases (e.g. history of myocardial infarction, abnormal heart rhythms) o Allergic reaction or auto immune diseases (e.g. type 1 diabetic, hay fever) o Metabolic disorders (e.g. type 2 diabetic) o Endocrinology disorders (e.g. Cushing Syndrome) o Haematological disorders (e.g. clothing problem) o Psychological/psychiatric disorders (e.g. depression, current high stress, Alzheimer disease) o Physical trauma for the last six weeks o Having the flue
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6575 |
| NTR-old | NTR6961 |
| CCMO | NL61404.029.18 |
| OMON | NL-OMON48587 |