We hypothesize that perturbation-based training improves the neuromuscular control of balance and gait by normalizing muscle coordination (expressed in terms of muscle synergies), in contrast to conventional physiotherapy.
ID
Bron
Verkorte titel
Aandoening
Stroke
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome measure will be the integrity of muscle synergies (i.e., coordinated muscle recruitment) before and after intervention.
Achtergrond van het onderzoek
Balance and gait problems are very important aspects of stroke-related disability, for which effective rehabilitation protocols are currently lacking. Preliminary evidence suggests that intensive, perturbation-based balance and gait training is able to improve the neuromuscular control of balance and gait, even in the chronic phase of stroke. Yet, the effects of perturbation-based training on the neuromuscular control of balance and gait remain to be established. This study will provide novel insights into the effects of perturbation-based training, thereby allowing for fine-grain characterization of the trajectories of motor recovery after stroke.
Doel van het onderzoek
We hypothesize that perturbation-based training improves the neuromuscular control of balance and gait by normalizing muscle coordination (expressed in terms of muscle synergies), in contrast to conventional physiotherapy.
Onderzoeksopzet
Week 1. Intake and clinimetric evaluation.
Week 2. Pre-intervention assessment of balance and gait.
Week 3-7. Experimental intervention group: perturbation-based training protocol for balance and gait. Regular care group: conventional physiotherapy.
Week 8. Post-intervention clinimetric evaluation and assessment of balance and gait.
Follow-up: Monthly collection of fall-registration cards for six months.
Onderzoeksproduct en/of interventie
Participants will be randomly assigned to either an experimental intervention or regular care group. The experimental intervention group will receive a perturbation-based training protocol in which an instrumented treadmill will induce reactive balance movements and gait adaptation during walking. The regular care group will receive conventional physiotherapy. Both groups will receive training in sessions of one hour, two times a week, during five weeks.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
To be eligible for participation, an individual must meet the following criteria:
- Having sustained a unilateral supratentorial stroke more than 6 months ago, with mild to moderate impairments.
- Able to stand and walk independently or under supervision (Functional Ambulation Categories ≥ 3).
- Completed inpatient rehabilitation
- Age 18 or older
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Potential participants who meet any of the following criteria will be excluded from participation:
- Conditions in which physical exercise is contra-indicated.
- Unable to walk for 10 minutes without walking aid.
- Receiving physiotherapy focusing on balance or gait that cannot be cancelled during participation in this study.
- Having received perturbation-based training with visual and/or mechanical perturbations in the previous year.
- Any other neurological or musculoskeletal conditions affecting balance.
- Current orthopaedic problems; hip or knee replacement, or limb amputation.
- Severe cognitive problems (Montreal Cognitive Assessment < 24).
- Persistent visuo-spatial neglect (Star-Cancellation Test ≤ 50).
- Use of psychotropic drugs or other medication negatively affecting balance.
- Behavioral problems interfering with compliance to the study protocol.
- Unable to stand for 15 minutes without orthosis or walking aid.
- Pregnancy.
- Unable to give consent.
Opzet
Deelname
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CCMO | NL67690.091.18 |
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