Wisselwerking tussen S. aureus en andere bacteriën in de neus

Rationale: This study will investigate the interaction between host nasal microbiome and Staphylococcus aureus to elicit the influence of host factors on success of dominant MRSA clones.

Objective: To identify nasal microbial communities associated with Staphylococcus aureus carriage and study the influence over time of S. aureus-targeted decolonization treatment on these microbial communities.

Study design: Prospective interventional cohort study with 2 groups.

Study population: A total of 70 healthy Dutch volunteers will be recruited to participate in the study. These volunteers will be grouped based on their S. aureus carrier status, either as carriers or noncarriers.

Intervention: After inclusion and determination of carrier status, all volunteers will be treated with Mupirocin (Bactroban) 2% nasal ointment and Chlorhexidine gluconate (Hibiscrub®) 4% cutaneous body wash solution within the product indication and in accordance with local clinical practice.

Main study parameters/endpoints: Microbiome composition of the nose, to be analysed in relation to S. aureus carrier status and decolonization.

After a two-week screening period for S. aureus nasal carriage, eligible volunteers are included and followed for 6 months.

5 day treatment with Bactroban 2% nasal ointment (mupirocin) and Hibiscrub 4% cutaneous solution (chlorhexidine gluconate) at the start of the study