We hypothezise that both hypertension in pregnancy and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction.
ID
Bron
Verkorte titel
Aandoening
cardiovascular disease; preeclampsia; endothelial dysfunction; diastolic dysfunction; women's health
cardiovasculaire aandoeningen; preeclampsie; endotheeldysfunctie; diastolische dysfunctie; gezondheid voor vrouwen
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
cardiovascular risk factors and diastolic funtion
Doel van het onderzoek
We hypothezise that both hypertension in pregnancy and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction.
Onderzoeksopzet
9-16 years postpartum; 1 visit
Onderzoeksproduct en/of interventie
questionnaire, antroprometrics, venous blood samples, cardiac ultrasonography.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Women with a history of early preeclampsia (<34 weeks gestation) who gave labour in the a UMC between 1998-2005 (cases)
Women with a history of uncomplicated pregnancy who gave labour after 37 weeks of gestation in a UMC between 1998-2005 and matched for age and delivery date (controls)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Multiple pregnancy, chronic hypertension, diabetes mellitus before pregnancy or gestational diabetes during the index pregnancy, cardiovascular disease before pregnancy, renal disease, coagulation disorders, pregnancy complicated by fetal anomalies. For controls exclusion: no pregnancies complicated by vascular complications.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5157 |
| NTR-old | NTR5297 |
| CCMO | NL38972.029.12 |
| OMON | NL-OMON45089 |