Endoscopic placement of fiducial markers in patients with gastric cancer is feasible and beneficial for patient position verification.
ID
Bron
Verkorte titel
Aandoening
Gastric cancer; radiotherapy
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Feasibility of using fiducial markers in image-guided pre-operative radiotherapy for patients with gastric cancer.
Achtergrond van het onderzoek
For pre-operative radiotherapy, the entire stomach with surrounding lymph nodes is included in the clinical target volume. However, the stomach is a highly mobile organ, displaying deformation and motion due to breathing, gastrointestinal filling and peristalsis. Daily cone-beam CT-based patient position verification is used, but visibility of the stomach on cone-beam CT (CBCT) is limited. In our study, we will investigate the feasibility and safety of endoscopic placement of fiducial markers in the stomach. We hypothesize that fiducial markers with high visibility on CT and CBCT benefit CBCT-based position verification and thus improve the accuracy of pre-operative radiotherapy for patients with gastric cancer.
Doel van het onderzoek
Endoscopic placement of fiducial markers in patients with gastric cancer is feasible and beneficial for patient position verification.
Onderzoeksopzet
Final analysis will take place after inclusion has been completed.
Onderzoeksproduct en/of interventie
Included patients will undergo endoscopic placement of fiducial markers in the stomach. In addition, extra imaging (CBCT and CT) will be obtained.
Publiek
Astrid Horst, van der
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
a.vanderhorst@amc.uva.nl
Wetenschappelijk
Astrid Horst, van der
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
a.vanderhorst@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Patients with histologically proven primary gastric cancer;
- Referred for pre-operative radiotherapy in the Academic Medical Center;
- Written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Coagulopathy or platelets level < 40.000;
- Endoscopic suspicion of fistula;
- Endoscopic suspicion of active gastric infections;
- High risk for sedation;
- Unwilling to participate in the study and/or sign informed consent;
- Pregnant;
- Age < 18 years.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7036 |
| NTR-old | NTR7241 |
| CCMO | NL65080.018.18 |
| OMON | NL-OMON50759 |