IVF culture medium affects parameters of metabolic syndrome at childhood stage
ID
Bron
Verkorte titel
Aandoening
In vitro fertilization (IVF)
Culture medium / Kweek medium
Cardiometabolic health / cardiometabole gezondheid
Growth / groei
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Length, height, skinfold thickness, blood pressure, endothelial function, lipid profile in blood, cortisol level
Achtergrond van het onderzoek
From animal studies it is known that embryo culture leads to growth, behavioural and cardio-metabolic alterations in the offspring. Embryo culture effects on human offspring have long been uninvestigated, until a few years ago when we found that the medium used to culture embryos in an IVF treatment has a significant effect on the incidence of low birth weight (LBW) and on birth weight. As this was the first randomized trial on embryo culture effects in human, nothing is known about health effects at later stages of development. Since a lower birth weight is related to an increased risk for (adult) chronic diseases belonging to metabolic syndrome (Barker theory), our findings raise concern for the IVF progeny. In advance of diseases at adult age, we hypothesize that IVF culture medium affects parameters of metabolic syndrome at childhood stage.
Doel van het onderzoek
IVF culture medium affects parameters of metabolic syndrome at childhood stage
Onderzoeksopzet
All children will be investigated at the age of 9 years old.
Onderzoeksproduct en/of interventie
The children in the IVF group are born after, as an embryo, being cultured in two different commercially available culture media. The two groups will be mutually compared as well as with a control group consisting of children that were conceived naturally.
Publiek
Dept. of Obstetrics and Gynaecology
Postbus 5800
A. Montfoort, van
P. Debyelaan 25
Maastricht 6202 AZ
The Netherlands
+ 31 43 3872012
aafke.van.montfoort@mumc.nl
Wetenschappelijk
Dept. of Obstetrics and Gynaecology
Postbus 5800
A. Montfoort, van
P. Debyelaan 25
Maastricht 6202 AZ
The Netherlands
+ 31 43 3872012
aafke.van.montfoort@mumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
IVF group: born after an IVF treatment at the MUMC applied in the period July 2003 – December 2006
CONTROL: 9 years old, singleton
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
IVF group: Born after preimplantation genetic diagnosis (PGD)
CONTROL1:conceived by any form of assisted reproduction
CONTROL 2:having a disorder that affects lipid profile or glucose metabolism
Opzet
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