Doxazosine voor PTSS, met name voor de slaapstoornissen.

1. Good speaking and writing in Dutch;

2. PDS above 18;

3. CAPS recurrent distressing dreams item score above 5 - CAPS difficulty falling or staying asleep item above 5;

4. No medication that affects sleep (e.g. contraceptives or analgetics like paracetamol are allowed);

5. No alcohol more than two consumptions a day;

6. Medication use of psychotropics has stopped at least one month before entrance of the study;

7. If psychotherapy has not been started yet it will not be initiated during the trial; If started it will be paused for the period of the study. Medication with influence on sleep-EEG will not be started during the study period (paracetamol and contraceptives are allowed).

Psychiatric:

1. Lifetime schizophrenia;

2. Schizoaffective disorder;

3. Bipolar disorder;

4. Severe depressive disorder;

5. Cognitive disorder;

6. Current delirium;

7. Substance use within 2 months of the study; alcohol is allowed if not
more than 2 consumptions a day;

8. Severe psychiatric instability (including evidence of being actively
suicidal or homicidal);

9. Any behavior which poses an immediate danger to patient or others.



Somatic:

1. Preexisting hypotension or (anamnestic) orthostatic hypotension;

2. Hypertension unless stable with help of anti-hypertensive medication;

3. Known for severe ischaemic heart disease;

4. Disease with strong reduced functioning of the liver;

5. Women of childbearing potential with either positive pregnancy test
or refusal to use effective birth control method;

6. Allergy or previous adverse reaction to doxazosin or other alpha-1
antagonist;

7. Hypersensitivity to quinazolinderivates;

8. Known for hypertrophy of the prostate without treatment;

9. Gastro-intestinal obstruction;

10. Oesophageal obstruction;

11. Overflow bladder or anuria with or without progressive renal insufficiency.