Diffusion Weighted MRI is an accurate imaging technique for detection of recurrent head and neck squamous cell carcinomas after (chemo)radiation therapy.
ID
Bron
Verkorte titel
Aandoening
squamous cell carcinoma, recurrence, radiotherapy
plaveiselcelcarcinoom, recidief, radiotherapie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The diagnostic performance of DW-MRI for the detection of recurrence in patients with clinical suspicion of recurrent or persistent HNSCC after initial (chemo) radiation will be primarily reflected by the PPV of DW-MRI. Furthermore, the NPV, discrimination, sensitivity and specificity will be assessed.
Achtergrond van het onderzoek
This study will investigate the accuracy of DW-MRI in detection of recurrent oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma after (chemo)radiation.
Doel van het onderzoek
Diffusion Weighted MRI is an accurate imaging technique for detection of recurrent head and neck squamous cell carcinomas after (chemo)radiation therapy.
Onderzoeksopzet
T0 = When there is a clinical suspicion of a recurrence;
T1 = 6 months post DW-MRI.
Onderzoeksproduct en/of interventie
One additional Diffusion Weighted MRI added to the regular imaging of choice.
Publiek
Dept. of Otolaryngology
Room G05.129
Heidelberglaan 100
Utrecht 3584 CX
The Netherlands
+31 (0)88 75 566 44
W.Grolman@umcutrecht.nl
Wetenschappelijk
Dept. of Otolaryngology
Room G05.129
Heidelberglaan 100
Utrecht 3584 CX
The Netherlands
+31 (0)88 75 566 44
W.Grolman@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with a oropharyngeal, hypopharyngeal, or laryngeal squamous cell carcinoma treated with (chemo)radiation with curative intent;
2. A clinical suspicion of a recurrence;
3. Last radiotherapy: > 2 months and < 3 years ago;
4. ‘Informed consent’ signed by patient;
5. Age ≥ 18 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients with contraindication for MRI or contrast agent;
2. Patients who received salvage surgery for the primary lesion;
3. Patients whom recurrence is so obvious that no additional imaging confirmation is necessary for the decision to take biopsies.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3024 |
| NTR-old | NTR3172 |
| CCMO | NL37889.041.11 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON35371 |