Sinus floor augmentation with microstructured BCP granules

Loss of teeth and molars is generally followed by alveolar bone resorption, which may lead to reduced bone height in the posterior maxilla. In order to regain bone volume in the posterior maxilla to allow for the placement of dental implants, maxillary sinus floor elevation is a common procedure. In this procedure, autologous bone graft is implanted on the bony floor of the maxillary sinus to increase the bone height. However, since the harvesting of autologous bone is associated with pain and donor-site morbidity, alternative strategies are being pursued. The current study compares a commercial bone graft substitute material called MagnetOs Granules versus the gold standard bone autograft in the maxillary sinus floor elevation procedure. The goal of this clinical trial is to determine whether MagnetOs Granules, a biphasic calcium phosphate ceramic with submicron surface topography, is an effective alternative to the gold standard for sinus floor elevation. A total of 30 patients will be included at the UMC Utrecht of which 15 patients shall be treated with MagnetOs Granules and 15 patients with bone autograft. Study endpoints will include the analysis of new bone formation in the sinus floor from biopsies, micro-CT analysis, implant stability measurements, gingival health check, patient-reported pain and adverse events, during a follow-up period of 17 months.

Microstructured BCP might be a suitable substitute to autologous bone graft in the sinus floor augmentation procedure

0, 5, 11, 17 months post-surgery

Patients will undergo sinus floor augmentation with either autologous bone graft or with micro-structured BCP granules.