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Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…
To evaluate the anti-inflammatory effects of 3 months statin therapy on vessel wall inflammation by means of FDG PET/CT in patients with CKD.
In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…
I. Test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in remitted MDD patients and HC: Pre-and peri-intervention changes will be examined using within-subject and between-group…
Cross-transmission of antibiotic-resistant pathogens can be prevented by using closed suction systems (CSS) instead of open suction systems (OSS) in mechanically ventilated ICU patients.
the prognosis of patients with severe RV failure after LVAD-implantation, post-cardiotomy or post-MI is grim, as medical treatment options are scarce. In a previous study, treatment with the Impella RP has been proven to be safe, feasible and…
1. The recognition of malnourished inpatients will improve by using the SNAQ malnutrition screening tool at admission; 2. Early recognition and treatment of malnutrition is effective and cost effective.
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…
Hard-core smokers are smokers who have been smoking for many years and who do not intend to quit. This makes them vulnerable to disease and death. Since hard-core smokers are unlikely to quit smoking, before aiming at actually quitting, we first…
Neurostimulation can improve collateral perfusion measured as a Pw/Pa ratio, during acute coronary occlusione.
We will test whether each component specifically reduces the risk factor it aims to target: Does component A (relational perspective based child-led play) improve the parent-child relationship, and not coercive parent-child interaction cycles or…
Objective: The overall aim of this project is to asses the prognostic value of the characteristics of an echocardiographic surrogate pressure-volume loop on mortality and morbidity due to PAH.
Improvement of the intestinal microflora of children consuming a fibre-enriched versus a standard paediatric tube feed.
Opening wedge HTO treated with DBM will better match one year post-operative mechanical axis alignement with pre-operative planned correction then opening wedeg HTO filled with autogenous iliac crest bone.
The time constant of oxygen uptake during recovery of submaximal exercise is a reliable parameter to measure effects of exercise training in patients with chronic heart failure.
Online treatment based on imagery rescripting is effective in the treatment of nightmares