142 resultaten
In the present placebo controlled study we will investigate the influence of valence on attention when viewing visual erotic stimuli. Especially when under the treatment condition of testosterone with sildenafil. In addition, we will investigate the…
We hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…
the correspondence between orosensation of sweetness and post-oral sensation of calories influences resting energy expenditure, cerebral blood flow and gastric emptying, and more specifically that the “not sweet enough” beverage, that contains more…
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
The Solace European Confirmatory (SOLECT) Trial is designed to determine whether the Solace Bladder Control System is safe and effective for the treatment of Stress Urinary Incontinence (SUI) in adult females.
What is the effect of carbohydrate infusion on food choice, food intake, satiety, hormones, dependent on the time of day and segment of the small intestine?
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
To determine the influence of the fatty beverage Cow’s milk on the systemic exposure (AUC) to erlotinib in patients with or without concomitant use of a PPI.
ETMI increases the detection rate of early neoplasia in BE patients with 40% or more compared to standard video endoscopy
Smoking cessation after development of coronary heart disease improves prognosis more than any other treatment and prevents future cardiovascular diseases. This study aims to provide hospitalized coronary heart disease patients who smoke with proven…
The main objective is to determine the change in CS parameters upon administration of tapentadol in comparison to pregabalin in patients suffering from chronic pain that has a visceral or deep somatic origin.
1. DKD patients are salt-sensitive due to a decreased sodium buffering capacity (damaged ESL). As a consequence a high sodium diet will lead to water retention, resulting in increased ECF, body weight and blood pressure. 2. CKD patients are salt-…
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
In line with results from recent pharmacological studies, it is expected that: 1. Inhibiting the cholinergic system by Inversine (Mecamylamine Hydrochloride) results in an impairment of disengagement, but will not affect bias; 2. Inhibiting the…
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
The administration of propranolol will inhibit the increase in dermal blood flow (DBF) induced by capsaicin application.
We want to examine the effects of both the adjustable rocker profile and the self-adjusting insole on in-shoe pressure in this patient group. We expect to find similar reductions in pressure as previously found in healthy subjects. Also, the…