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We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Reduced dermal blood flow response to capsaicin application and saline iontophoresis after propranolol ocompared to placebo administration.
Pelvic floor muscle spasms resulting in chronic pelvic pain may occur as a primary event or secondary to a physical, psychological or pathological factor. First-line treatment consists of pelvic floor physiotherapy. When first-line treatment fails,…
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP
It is expected that acute challenges with cocaine will induce two opposing effect on creativity. That is, cocaine will increase mood leading to enhancement in divergent but not in convergent thinking.
Rivastigmine can reverse a memory impairment that is induced by biperiden, which will be seen both behaviorally and in the EEG.
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressions. Unfortunately, several cognitive side effects with a large pallet of different manifestations and impact often occur. For instance, postictal agitation ((PIA)…
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
The administration of propranolol will inhibit the increase in dermal blood flow (DBF) induced by capsaicin application.
Whether the bioavailability of ciprofloxacin oral suspension and tablets are equivalent and can therefore be used interchangeably.
We hypothesized that adding alimemazine to existing ADHD treatment will decrease ADHD-symptoms as reported by parents and school teachers as well as allergic symptoms.
Pulse oximetry is a non-invasive method allowing monitoring of the oxygen saturation of a patient. For many years now, it has been used in secondary care with great success. Recently, it is noticed that pulse oximetry is used more often in the…
- Dapagliflozin decreases albuminuria - The response to dapagliflozin is variable in albuminuria - The response in blood glucose, blood pressure, body weight and albuminuria varies within an individual
This study examines the effect of The Phase Out treatment on chronic, incurable tinnitus in adult subjects in comparison with placebo sound. The expectation of this study is that Phase Out treatment is effective for a longer duration and results in…
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…
The present mode of (tonic) SCS is accompanied by paraesthesia in the area of stimulation. Recently, a new mode of SCS has been developed which makes it possible to apply spinal cord stimulation without paraesthesias. This mode is called burst…
Chronic chilblains is a common disease causing major restrictions in daily life, nevertheless little is known about treatment. In a literature search, we found thin evidence of three interventions: fluocinolone cream, nifedipine and vitamin D3.…
During treatment with dexamethasone, the deprived mineralocorticoid receptor may cause serious cerebral side effects. Hence, it is feasible that these side effects on mood, behaviour and cognition could be prevented, by an intervention with a…
Due to the difference in mineralocorticoid characteristics between prednisolone and dexamethasone, it is hypothesized that dexamethasone will have a greater effect then prednisolone, especially when assessing neurocognitive function and blood…
The present study explores the dose-response relationship in LSD-induced subjective and cognitive effects using small doses of LSD (5, 10, and 20 µg) compared to placebo. The study hypothesis is that higher doses of LSD will be associated with…