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Compared to treatment as usual implementing Integrated Double Diagnosis Treatment (IDDT) in mental health care teams for severe mental illness (SMI) outpatient will improve a. outcomes at psychiatric symptoms and drug or alcohol abuse, and b. will…
We expect higher bioavailability of seaweed types containing more inorganic iodine, compared to seaweed types containing more or organic iodine.
Timing and dosing of BH4 potentially impacts Phe and Tyr variation in PKU patients treated with BH4 and thus potentially impacts outcome.
Chronic chilblains is a common disease causing major restrictions in daily life, nevertheless little is known about treatment. In a literature search, we found thin evidence of three interventions: fluocinolone cream, nifedipine and vitamin D3.…
Inhalation of salbutamol in a forward leaning body posture with the head flexed backwards leads to more reversibility of lung function compared to inhalation with the standard body posture during spirometry in asthmatic children.
During treatment with dexamethasone, the deprived mineralocorticoid receptor may cause serious cerebral side effects. Hence, it is feasible that these side effects on mood, behaviour and cognition could be prevented, by an intervention with a…
Due to the difference in mineralocorticoid characteristics between prednisolone and dexamethasone, it is hypothesized that dexamethasone will have a greater effect then prednisolone, especially when assessing neurocognitive function and blood…
Elevated levels of Free Fatty Acids during fasting induce oxidative stress and cause insulin resistance to maintain euglycemia.
One-stage breast reconstruction with contralateral mammaplasty using a breast sharing procedure is an oncologically safe concept.
Cast treatment is not inferior to surgical open reduction and internal fixation in terms of patient related outcome measurements.
The flavonoid-drug interaction could potentially lead to higher nintedanib absorption by the gastro-intestinal tract. This would cause higher systemic bioavailability and lower local gastro-intestinal drug concentrations. Furthermore, inter-patient…
The present study explores the dose-response relationship in LSD-induced subjective and cognitive effects using small doses of LSD (5, 10, and 20 µg) compared to placebo. The study hypothesis is that higher doses of LSD will be associated with…
In adult Fontan patients, treatment with bosentan, an endothelin receptor antaganost (ERA) lowers the pulmonary vascular resistance, which may result in improvement of the cardiopulmonary circulation and functional capacity.
It is predicted that pretreatment with memantine can prevent the memory impairment that is usualy caused by MDMA.
We hypothesize that the ceftriaxone monotherapy strategy is non-inferior for mortality and for nephrotoxicity a strategy of ceftriaxone monotherapy is superior to a strategy of cefuroxime combined with short course aminoglycosides.
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
Primary 1. An immediate invasive approach (immediate angiography and revascularization when appropriate) results in a reduction of the combined incidence of death, re-infarction or recurrent ischemia at 30 days follow-up. Secondary 1. An immediate…
1. High school Freshman develop less positive attitudes towards substance use after participation in Fresh Start than high school freshman in the waitlist control condition. 2. Fresh Start is more effective when it is implemented at the beginning of…