84 resultaten
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
Cross-transmission of antibiotic-resistant pathogens can be prevented by using closed suction systems (CSS) instead of open suction systems (OSS) in mechanically ventilated ICU patients.
Improvement of the intestinal microflora of children consuming a fibre-enriched versus a standard paediatric tube feed.
The time constant of oxygen uptake during recovery of submaximal exercise is a reliable parameter to measure effects of exercise training in patients with chronic heart failure.
Different processing of milk products will have impact on metabolic availability of amino acid
Overall: when kidney function deteriorates, regulation of the potassium balance in response to potassium loading switches from renal to non-renal mechanisms. 1. Serum potassium in CKD is mainly influenced by alterations in the internal potassium…
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
Prolonged ingestion of chocolate milk during a training program improves the sports performance parameters in badminton athletes more than control.
Measurement of airways hyperresponsiveness by mannitol (Aridol©) as compared to methacholine saves time to the lung function technician, while being as sensitive to discern hyperresponsive from normo-responsive, and being at least equally acceptable…
Depressive symptom severity is reduced more by active DBS than sham DBS.
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
Cholesterol lowering by low fat diet and lovastatin will also reduce very long chain fatty acids in patients with X-ALD.
This is an exploratory pilot study without specific hypotheses.
The optimal management of locoregionally advanced NSCLC is evolving. Multimodality treatment is rapidly becoming the most common approach to stage III NSCLC. ASCO guidelines recommend initial chemotherapy (platinum-based, 2 or 3 cycles) combined…
Hypothesis 1: the Groningen ULR and the Provox®2 are the same in terms of the replacement method, the burden on the patient and the convenience of the replacement and of the resistance during phonation. Hypothesis 2: the Groningen ULR has a longer…
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.
We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…
To determine the influence of oral medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel and their respective metabolites in cancer patients.