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The flavonoid-drug interaction could potentially lead to higher nintedanib absorption by the gastro-intestinal tract. This would cause higher systemic bioavailability and lower local gastro-intestinal drug concentrations. Furthermore, inter-patient…
A relationship exists between a pharmacologic effect of ENX-201 and the plasma concentration
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
Adding specific components designed to target three risk factors for child maltreatment (parental stress, parental anger, and post-traumatic stress symptoms) to an evidence-based home visiting program alleviates these specific risk factors.
Infant formulae with higher levels of milk fat result in improved microbiota composition as compared to standard formula.
exercise improves social functioning, quality of life and decreases symptom severity
Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.
The post-prandial rise in total amino acid, proline and glycine concentration following a single bout of resistance exercise will be the highest in the 20 gr whey combined with 10 gr collagen compared to all other test drinks
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
Overall, diagnostic accuracy will be lower on subjected-to-bias than on not-subjected-to-bias cases, but the difference in accuracy will be smaller in the group of physicians with higher knowledge of critical diagnostic features. Overall, the…
We hypothesize that trimetazidine improves left ventricular diastolic dysfunction in HFpEF, by improving mitochondrial function and increasing myocardial energy content
3D-vision during robotic PJ and HJ biotissue anastomoses will reduce procedure time and improve surgical performance as compared to 2D-vision.
It is hypothesized that Ziverel tackles esophageal hypersensitivity by protecting the mucosal barrier function.
We expect that the shape of the cracker influences the amount of cheese consumers will add to their cracker (increase / decrease cheese intake). In addition, we expect that increased cheese viscosity increases oro-sensory exposure time (increased…
After calcitriol treatment, i. resting state striatal neuronal activity, i.e. BOLD signal, is increased and ii. visual food stimuli-induced neuronal activity of brain areas involved in food intake is reduced.
Polystyrene sulfonate shows an in-vitro binding interaction with amitriptyline, causing 70-80% binding of amitriptyline to polystyrene sulfonate. The hypothesis is that polystyrene sulfonate binds to amitriptyline when taken simoultaneously in…
With personal control system, people feel more comfortable.
The intended research aims to evaluate whether a better suppression of adrenal androgens, so a better hormonal setting, can be achieved by changing the time of the highest dose in the morning or in the evening.
1. The addition of moderate positive end-expiratory pressure (PEEP, 7.5 cmH2O) to high inspiratory fractions of oxygen can either improve oxygenation or reduce respiratory rate, or both, in patients with severe Covid-19 pneumonia 2. The application…
Acute whole-body heat treatment beneficially affects hepatic insulin sensitivity