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We hypothesize that TIPS placement has an significant effect on drug metabolism and bile acid metabolism.
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
This study aims to establish a plasmakinetic profile of GABA from tomatoes in healthy men and compare it to the kinetic profile of GABA from a supplement. In addition, the effects of glutamate (precursor of GABA) on the plasma-time curves of GABA…
It is hypothesized that Ziverel tackles esophageal hypersensitivity by protecting the mucosal barrier function.
Infant formulae with higher levels of milk fat result in improved microbiota composition as compared to standard formula.
3D-vision during robotic PJ and HJ biotissue anastomoses will reduce procedure time and improve surgical performance as compared to 2D-vision.
We expect that the shape of the cracker influences the amount of cheese consumers will add to their cracker (increase / decrease cheese intake). In addition, we expect that increased cheese viscosity increases oro-sensory exposure time (increased…
After calcitriol treatment, i. resting state striatal neuronal activity, i.e. BOLD signal, is increased and ii. visual food stimuli-induced neuronal activity of brain areas involved in food intake is reduced.
We hypothesize that trimetazidine improves left ventricular diastolic dysfunction in HFpEF, by improving mitochondrial function and increasing myocardial energy content
With personal control system, people feel more comfortable.
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.
Overall: when kidney function deteriorates, regulation of the potassium balance in response to potassium loading switches from renal to non-renal mechanisms. 1. Serum potassium in CKD is mainly influenced by alterations in the internal potassium…
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
Depressive symptom severity is reduced more by active DBS than sham DBS.
Acute whole-body heat treatment beneficially affects hepatic insulin sensitivity
To investigate the acute responses occuring in the esophageal mucosa of EoE patients after local allergen provocation
We hypothesize that providing an attractive game with appropriate metaphors and personalized feedback and feedforward will positively impact the quality of home spirometry in asthmatic children.