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We hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Reduced dermal blood flow response to capsaicin application and saline iontophoresis after propranolol ocompared to placebo administration.
What is the effect of carbohydrate infusion on food choice, food intake, satiety, hormones, dependent on the time of day and segment of the small intestine?
The effects of a brief compassion induction exercise will be compared to the effects of a neutral exercise. We hypothesize that a brief compassion induction in a sample of patients with PD will facilitate the choice of more adaptive emotion…
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
This study is therefore aimed at quantifying the relative contribution of the two major receptor systhems involved in S(+) ketamine and methadone induced analgesia and side effects( respiratory depression,sedation,miosis).
The primary objective is to compare the pharmacokinetic profile of tacrolimus after rectal and sublingual administration with oral administration.
In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…
Cross-transmission of antibiotic-resistant pathogens can be prevented by using closed suction systems (CSS) instead of open suction systems (OSS) in mechanically ventilated ICU patients.
Objective: The overall aim of this project is to asses the prognostic value of the characteristics of an echocardiographic surrogate pressure-volume loop on mortality and morbidity due to PAH.
Pelvic floor muscle spasms resulting in chronic pelvic pain may occur as a primary event or secondary to a physical, psychological or pathological factor. First-line treatment consists of pelvic floor physiotherapy. When first-line treatment fails,…
Different processing of milk products will have impact on metabolic availability of amino acid
We want to examine the effects of both the adjustable rocker profile and the self-adjusting insole on in-shoe pressure in this patient group. We expect to find similar reductions in pressure as previously found in healthy subjects. Also, the…
It is hypothesized that respiratory depression from the opioid oxycodone will increase with concomitant administration of alcohol. Furthermore it is hypothesized that the increase in respiratory depression is not only dependent on the dosage of…
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP
It is expected that oliceridine has a better profile concerning dose-related analgesia and dose-related side effects, compared to morphine.
To evaluate the effects of a versatile web-based health game on cognition and compliance in Parkinson’s disease with mild cognitive impairment.
Subcutaneous immunoglobuline therapy is as effective as intravenous immunoglobuline therapy in maintaining muscle strength in patients with multifocal motor neuropathy
By introducing of PK-guided individualized dosing of pazopanib we hypothesize that the interpatient variability can be reduced by 50%.