34 resultaten
We hypothesize that by using different imaging techniques, we can give a good characterization of the bone marrow microenvironment in advanced-stage myelofibrosis, before and during treatment with ruxolitinib.
About 10-15% of the population suffers from chronic insomnia. Structurally poor sleep can have unpleasant consequences for people's health and quality of life. Therefore, proper treatments are of great importance. Fortunately, Cognitive…
Monitoring a patient’s oxygen status during anesthesia using pulse oximetry is essential. The new Oxygen Reserve Index (ORI) may help provide clinicians real-time visibility to oxygenation in a moderate hypoxic range and serve as a warning of an…
Aim of the study is to determine how often muscle strength measurements should be repeated, using a hand-held dynamometer to obtain a maximal muscle strength measurement
Painreduction for 67% of patients with a locally advanced or local recurrent pancreatic carcinoma through a short radiotherapy scheme (single arm phase 2 study)
There seems to be a biphasic process of bone mineral density (BMD) changes in osetoarthritis (OA). An increased bone mineral density (BMD) and a specific distribution of BMD in the cortical of the subchondral plates and below in the trabecular bone…
Several reasons for clozapine discontinuation are known, but the current evidence identifying patients who are at risk of discontinuation of clozapine is small and not always consistent. Also cultural differences may question if international…
Objectives are: 1) To determine the feasibility of an OA educational self-management course, by assessing the appreciation of health care providers and participants, participation and barriers and facilitators to participation. 2) To determine…
To analyse the diagnostic and prognostic value of plasma EV protein/miRNA and gene expression profiles of circulating cells for objectified ischemic coronary artery disease in patients with symptoms (e.g. chest pain) suggestive of coronary artery…
Non invasive hemodynamic monitoring is as good as invasive monitoring
What are the motivations of women in the Netherlands to choose UC and what are their beliefs on childbirth in general and in relation to current Dutch maternity care? This study primarily aims at understanding women’s motivations in declining (parts…
The rationale for this study is to assess the visibility and positional accuracy of the laser marks. Combined with VLE imagery, the targeting enabled by the laser marking system could have the potential to increase the diagnostic accuracy of current…
Differences in the healthcare, workplace, legislative, and personal systems (see figure) as well as evaluator and patient characteristics may better explain differences in FCE results
We hypothesise that accurate treatment of GOLD D patients in an integrated primary care system will improve patient outcomes over 12 months.
PolyEthylene Glycol with ascorbic acid (PEG-asc) bowel cleansing preparation could contribute to the development of low potassium values. Hypokalemia is partially a pre-existing matter before bowel cleansing. Elderly are at risk for development of…
This study examines the interplay between adolescents’ peer relations and molecular genetics in predicting risk behaviors. The central question is: How do molecular genetic information and peer dynamics interplay in explaining adolescent risk…
To explore the short term safety and tolerability of 2-IB and the pharmacokinetic profile of 2-IB when given on top of therapeutic hypothermia
Radium-223 is the 5th treatment for metastasized castration resistant prostate cancer with a proven overall survival benefit. The improved survival of Radium-223 over placebo was demonstrated in the ALSYMPCA trial, which included a miscellaneous…
Visceral obesity and sarcopenia are associated with increased risk of postoperative complications in colorectal cancer surgery.