313 resultaten
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
We hypothesize that in critically ill patients, measuring the anti-factor-Xa randomly in a 3 to 5 hours timeframe, may introduce a significant variation in the measured anti-factor-Xa and can seriously underestimate the real peak anti-factor-Xa.
A 12 weekly computer-tailored coaching program reduces sedentary behavior. Perceived bodily pain, mental health, vitality, stress, and performance are expected to lower by the means of reduced sitting time.
Exploratory study investigating the efficacy of the currently recommended dosing regimen of ciprofloxacin prophylaxis in patients treated for haematological malignancies.
Fiducial markers placed on endoscopically determined tumor borders are a good surrogate for macroscopic tumor.
It is an observational study, no null hypothesis has been formulated. The purpose of StEM is to understand the expectations, needs, experiences, choices and decisions of pregnant women and women who recently gave birth in the Netherlands, recording…
High-resolution ultrasound (HRUS) is a quick and cost-effective technique to study the morphology of peripheral nerves. Sonographic characteristics of plexiform neurofibromas and MPNST have been described in the literature. Recently, a pilot study…
Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…
We hypothesize that DVT can be safely ruled out by the LEFt rule in combination with the D-dimer test in 5-10% of pregnant women, and that a normal MRDTI safely rules out isolated pelvic vein thrombosis. We hypothesize that 7-10% of performed MRDTI’…
Fecal Immunochemical Testing as a Tool to Determine the Need for Colonoscopy in Symptomatic Patients
Using two FIT tests in symptomatic patients prior to colonoscopy can be a useful preselection tool to determine the need for colonoscopy in symptomatic patients.
We hypothesize that subjects with NASH produce more ethanol after a mixed meal tolerance test than subjects with a healthy liver after receiving a infusion with fomepizole.
Biomarkers for predicting disease severity in emergency department patients with suspected infection
Novel biomarkers can aid in the early identification of sepsis, and can be useful for risk stratification at the ED in patients with a suspected infection.
We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of…
We hypothesize that in many patients there will be an inconsistency between administrating medication and registration in the EHR of more than 15 minutes. Making retrospective studies drawing conclusions on data from the EHR less reliable.
The combination of PARP and PD-L1 inhibition has a synergistic effect and will result in progression free survival improvement.
The hypothesis is that twins discordant for pregnancy complications display a distinct epigenetic signature in MSCs. This signature contributes to cellular metabolic alterations and is associated with future cardiovascular and neurodevelopmental…
Not applicable
The goal of the proposed study is to test the null hypothesis that vaccination will not boost the cytotoxic T cell responses against UTA2-1 in >20% of the patients.
The pharmacokinetics of erlotinib 150mg QD is comparable to the pharmacokinetics erlotinib 75mg + ritonavir 200mg QD.
PPI administration to women with confirmed PE lowers sFlt-1 levels and which may lead to less complications or progression of disease.