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We want to establish an abbreviated, multidimensional, evidence based, diagnostic personalityprotocol within the mental health services. The hypothesis is that the mutidimensional testcombination of VTCI, NEO-FFI and CISS is sufficient reliable and…
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
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Glucose control by closed loop in diabetes type 1 is equal to glucose control by insulin pump.
The fetus is protected from maternal immune responses through various mechanisms such as lack of expression of classical HLA class I and class II molecules, inhibitory T cell, costimulatory molecules, NK cells, complement regulatory proteins by…
1. The STERK-intervention will prevent early onset of anxiety and mood disorders in offspring (compared to a minimal information condition); 2. The STERK-intervention is cost-effective; 3. The effectiveness of the STERK-training will be influenced…
Increased cardiac sympathetic activity is highly prevalent among patienst with chronic heart failure. The increased cardiac sympathetic activity as assessed with 123I-metaiodobenzylguanidine (MIBG) is a usefull tool to discriminate responders (i.e.…
The present study aims to get more insight into the use of oral anticancer agents in daily practice.
The aim of this study is to provide evidence based dosing guidelines for vincristine in combination with azoles. Therefore we will study the pharmacokinetics of vincristine with and without concomitant azole therapy in pediatric patients with acute…
It is safe to withhold intravenous broad-spectrum antibiotics in low-risk pediatric cancer patients and to shorten antibiotic treatment in a subgroup of medium-risk pediatric cancer patients presenting with febrile neutropenia.
The OptiScanner provides accurate blood glucose levels in critically ill patients.
Chronic heart failure (CHF) is a clinical syndrome resulting from a decreased cardiac output, insufficient to maintain adequate tissue oxygenation. Eventually, inadequate tissue oxygenation will lead to pathological alterations, especially at the…
1. Describe concomittant electrical activation of endocardial and epicardial layers of atrium that have been shown in animal models to be dissociated, and to be involved in the perpetuation of AF; 2. Describe with a density mapping catheter the…
Nowadays after every venous treatment some form of compressive treatment is prescribed. Its use has been proven for surgical interventions, but is unclear for EVLT. Patients often think of wearing of these stockings as a burden.Therefore we will…
The primary objective is to quantify the learning process of self infusion and the self infusion procedure.
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The aim of the meta-analysis is to investigate the early predictive value of migration measured by RSA 1 year post-operatively for revision for aseptic loosening of the femoral component in THA and to compose migration thresholds for safe and…
The electrohysterogram is better predictor of preterm delivery than current diagnostics.
Non inferiority of wide field imaging compared with ophthalmoscopy.
We hypothesize that the perturbed interplay between certain constituents of the microbiota and the host is caused by invading organisms, which after crossing the epithelial barrier are capable of inciting and/or persisting an unbalanced innate…