831 resultaten
The fetus is protected from maternal immune responses through various mechanisms such as lack of expression of classical HLA class I and class II molecules, inhibitory T cell, costimulatory molecules, NK cells, complement regulatory proteins by…
This study will explore the feasibility of post-transplant panobinostat combined with decitabine after reduced intensity conditioning (RIC) alloHSCT in patients with (very) poor-risk AMLor RAEB with IPSS >= 1.5 (AML/RAEB). While recent…
If the 'level of fitness dependant protocol' produces a higher VO2-max in comparison with the adapted Bruce protocol, then a relevant difference can be shown when the results are statistically analysed.
Informed consent procedures and information provision differs between different transplantation centers and transplantation professionals in The Netherlands. Donor knowledge and satisfaction may be influenced by the manner of information provision…
1. To assess the safety and tolerability of different doses of a single IV injection of OTL-038 2. To assess the efficacy of ascending doses of a single IV injection of OTL-038 in detecting ovarian, renal cell or endometrial cancer during surgery by…
“Personalized Prevention Approach for CardioMetabolic Risk” (PPA CMR), a prevention program for cardiometabolic disease (CMD) combined with an individualized lifestyle intervention, is effectiveness and cost-effectiveness when implemented in primary…
Casein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (…
Patients with COVID-19 related CRS treated with immunosuppressive treatment have better clinical outcomes compared to patients treated according to standard care.
We hypothesize that subjects with NASH produce more ethanol after a mixed meal tolerance test than subjects with a healthy liver after receiving a infusion with fomepizole.
Biomarkers for predicting disease severity in emergency department patients with suspected infection
Novel biomarkers can aid in the early identification of sepsis, and can be useful for risk stratification at the ED in patients with a suspected infection.
Regarding our main objectives, we hypothesize that patients with a gambling disorder show an increase in dopamine synthesis capacity. Moreover, we hypothesize a positive relationship between individual differences in dopamine synthesis capacity and…
The objective of the study is to identify factors associated with anterior knee pain after primary total knee replacement.
1. The STERK-intervention will prevent early onset of anxiety and mood disorders in offspring (compared to a minimal information condition); 2. The STERK-intervention is cost-effective; 3. The effectiveness of the STERK-training will be influenced…
A decline of intra-tumoral concentrations over time could be the first sign of the development of drug resistance by the tumor. In this exploratory study we will investigate the relationship between plasma and intra-tumoral paclitaxel concentrations…
The preoccupation with the paranoid delusion decreases after intervention with EMDR Flash Forward
We hypothesise that HCP provides reproducible and accurate measurements of LV volume changes during different CRT pacing settings which are comparable with invasive conductance catheter measurements.
We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of…
A positive effect of the study product in preventing asthma like symptoms in infants at high risk for developing asthma later in childhood.
We hypothesize that in many patients there will be an inconsistency between administrating medication and registration in the EHR of more than 15 minutes. Making retrospective studies drawing conclusions on data from the EHR less reliable.