132 resultaten
We want to establish an abbreviated, multidimensional, evidence based, diagnostic personalityprotocol within the mental health services. The hypothesis is that the mutidimensional testcombination of VTCI, NEO-FFI and CISS is sufficient reliable and…
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
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Glucose control by closed loop in diabetes type 1 is equal to glucose control by insulin pump.
1. The STERK-intervention will prevent early onset of anxiety and mood disorders in offspring (compared to a minimal information condition); 2. The STERK-intervention is cost-effective; 3. The effectiveness of the STERK-training will be influenced…
1. Muscle ultrasound is capable to detect dermatomyositis and polymyositis in suspected patients; 2. Muscle ultrasound is capable to detect improvement of structural muscle changes induced by treatment; 3. Muscle ultrasound is capable to detect…
The primary goal of this study is to determine whether it is possible to discontinue treatment with TNF blocking therapy in patients suffering from Rheumatoid Arthritis when the patient has had stable low disease activity.
Increasing kidney function by kidney transplantation might improve the circadian rhythms of melatonin concentration, sleep and 24-hour blood pressure profile.
1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…
Increased cardiac sympathetic activity is highly prevalent among patienst with chronic heart failure. The increased cardiac sympathetic activity as assessed with 123I-metaiodobenzylguanidine (MIBG) is a usefull tool to discriminate responders (i.e.…
The present study aims to get more insight into the use of oral anticancer agents in daily practice.
The aim of this study is to provide evidence based dosing guidelines for vincristine in combination with azoles. Therefore we will study the pharmacokinetics of vincristine with and without concomitant azole therapy in pediatric patients with acute…
It is safe to withhold intravenous broad-spectrum antibiotics in low-risk pediatric cancer patients and to shorten antibiotic treatment in a subgroup of medium-risk pediatric cancer patients presenting with febrile neutropenia.
The OptiScanner provides accurate blood glucose levels in critically ill patients.
We aim to use Epstein-Barr Virus (EBV) within nasopharyngeal carcinoma (NPC) tumour cells as therapeutic target. In these cells EBV “hides” in a latent state due to methylation of the viral promoters, expressing only few non-immunogenic viral…
Remote ischemic preconditioning (RIPC) has been shown to attenuate myocardial damage in cardiac surgery. We hypthesize that RIPC induced cardioprotection is associated with an increased amount of mitochondrial hexokinase.
1. The first hypothesis is that treatment of panic disorders with or without agoraphobia with EMDR as well as with CBT will lead to symptom reduction. This symptom reduction is expected to be larger in the EMDR treatment group than in the CBT…
Chronic heart failure (CHF) is a clinical syndrome resulting from a decreased cardiac output, insufficient to maintain adequate tissue oxygenation. Eventually, inadequate tissue oxygenation will lead to pathological alterations, especially at the…
The primary objective is to quantify the learning process of self infusion and the self infusion procedure.
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